Table 3 Serotonin metabolism genes and typical migraine genetics
From: The primary headaches: genetics, epigenetics and a behavioural genetic model
Serotonin metabolism genes examined | Phenotypes |
|---|---|
5-HTSERT (17q11.2–12) | Allelic association with MO (increase of allele STin2.12 + decrease of allele STin2.10) and MA (same + increase of allele Stin2.9) [102]; 5HT-TLPR with MA [103] |
Allelic association with migraine (allele Stin2.10) [104]; borderline association with migraine [105] | |
5-HT2A (13q14–21) | Allelic (allele C) association with migraine aura [108] |
5-HT1B (6q13) | |
5-HT1D (1p36.3–34.3) | |
5-HT2B (2q36.3–q37.1) | |
5-HT2C (Xq22–25) | |
5-HT1B (6q13) | No association with therapeutic response to triptans [112, 113] |
5-HT1F (3p12) | No association with therapeutic response to triptans [112, 113] |