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Cluster headache and intracranial aneurysm


In the present study we describe the cases of two patients with cluster-like headache related to intracranial carotid artery aneurysm. One of these patients responded to verapamil prescription with headache resolution. In both cases the surgical clipping of the aneurysm resolved the cluster pain. These findings strongly suggest a pathophysiological link between the two conditions. The authors discuss the potential pathophysiological mechanisms underlying cluster-like headache due to intracranial carotid artery aneurysm.


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Correspondence to Marcelo Moraes Valença.

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Valença, M.M., Andrade-Valença, L.P.A., Martins, C. et al. Cluster headache and intracranial aneurysm. J Headache Pain 8, 277–282 (2007).

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  • Cerebral aneurysm
  • Cluster headache
  • Parasympathetic
  • Third cranial nerve
  • Internal carotid artery
  • Pathophysiology