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  • Original
  • Open Access

Cluster headache and intracranial aneurysm

  • 1Email author,
  • 2,
  • 1,
  • 1,
  • 1,
  • 3 and
  • 1
The Journal of Headache and Pain20078:412

  • Received: 27 December 2006
  • Accepted: 14 September 2007
  • Published:


In the present study we describe the cases of two patients with cluster-like headache related to intracranial carotid artery aneurysm. One of these patients responded to verapamil prescription with headache resolution. In both cases the surgical clipping of the aneurysm resolved the cluster pain. These findings strongly suggest a pathophysiological link between the two conditions. The authors discuss the potential pathophysiological mechanisms underlying cluster-like headache due to intracranial carotid artery aneurysm.


  • Cerebral aneurysm
  • Cluster headache
  • Parasympathetic
  • Third cranial nerve
  • Internal carotid artery
  • Pathophysiology


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