Skip to main content
  • Brief Report
  • Published:

Cluster headache attacks and multiple sclerosis

Abstract

We report the case of a patient who developed typical cluster headache attacks and was diagnosed as having multiple sclerosis (MS) at the same time. The headache attacks resolved after i.v. treatment with methylprednisolone. MR imaging showed a pontine demyelinating lesion involving the trigeminal nerve root inlet area, on the same side as the pain. The association between cluster headache and MS has been rarely described before. This case suggests that in patients with cluster headache neuroimaging is often useful in order to exclude structural lesions.

References

  1. Elkbom K (1999) Cluster headache: a clinical and pathophysiological overview. In: Olesen J, Goadsby PJ (eds) Cluster headache and related conditions, Oxford University Press, Oxford, pp 14–22

    Google Scholar 

  2. Headache Classification Subcommittee of the International Headache Society (2004). The International Classification of Headache Disorders — 2nd Edition. Cephalalgia 24(Suppl 1):1–151

    Google Scholar 

  3. Giraud P, Jouanneau E, Borson-Chazot F et al (2002) Cluster-like headache: literature review. J Headache Pain 3:71–78

    Article  Google Scholar 

  4. Favier I, van Vliet JA, Roon KI et al (2007) Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases. Arch Neurol 64:25–31

    Article  PubMed  Google Scholar 

  5. Leandri M, Cruccu G, Gottlieb A (1999). Cluster headache-like pain in multiple sclerosis. Cephalalgia 19:732–734

    Article  PubMed  CAS  Google Scholar 

  6. Then Berg F, Dose T, Forderreuther S et al (2000). Symptomatischer Clusterkopfschmerz. Ausdruck eines MS-Schubes mit kernspintomographischem N achweis einer pontomedullären Läsion des ipsilateralen Trigeminuskerngiebetes. Nervenarzt 71:1000–1002

    Article  Google Scholar 

  7. Polman CH, Reingold SC, Edan G et al (2005) Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol 58:840–846

    Article  PubMed  Google Scholar 

  8. Almarcegui C, Lorente S, Romero MF et al (1999) Blink reflex in trigeminal hypoesthesia caused by a pontine demyelinating lesion. J Neurol 246:140–141

    Article  PubMed  CAS  Google Scholar 

  9. Love S, Gradidge T, Coakham HB (2001) Trigeminal neuralgia due to multiple sclerosis: ultrastructural findings in trigeminale rhizotomy specimens. Neuropathol Appl Neurobiol 27:238–244

    Article  PubMed  CAS  Google Scholar 

  10. Matharu MS, Goadsby PJ (2002) Persistence of attacks of cluster headache after trigeminal nerve root section. Brain 125:976–84

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Salvatore Gentile.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gentile, S., Ferrero, M., Vaula, G. et al. Cluster headache attacks and multiple sclerosis. J Headache Pain 8, 245–247 (2007). https://doi.org/10.1007/s10194-007-0405-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10194-007-0405-8

Keywords