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Genetic association study and meta-analysis of the HTR2C Cys23Ser polymorphism and migraine

The Journal of Headache and Pain volume 8, pages 231–235 (2007)Cite this article

Abstract

The objectives of this study were to determine if the HTR2C Cys23Ser polymorphism is associated with migraine in a case-control study, and to perform a meta-analysis with present and previous available studies. The HTR2C gene is located at the Xq24-q28 chromosomal band. This band was linked to migraine with aura (MA) in two Australian families. Using the HTR2C Cys23Ser allelic variant, this gene has been ruled out as a migraine gene in 3 out of 4 studies. Only the Japanese study reported a higher risk for MA (OR=6.11; 95% CI=1.70−21.97, p trend<0.01). We performed a case-control study with 335 migraine subjects and 335 sex- and age-matched controls, and a meta-analysis pooling the results of the available data from MA subsets of patients. In the association study we found no significant differences among migraine and MA patients for this polymorphism. In the meta-analysis, under the fixed-effect model, the Ser allele did not confer higher risk for suffering MA (pooled OR=1.1; 99% CI=0.8−1.5, p=0.499). Our study did not confirm the HTR2C Cys23Ser polymorphism as a risk factor for migraine and MA.

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Authors and Affiliations

  1. Service of Neurology, University Hospital “Marques de Valdecilla”, E-39008, Santander, Spain

    Agustin Oterino, Julio Pascual, Amalia Cayon, Ana Alonso & Natalia Valle

  2. Service of Microbiology, University Hospital “Marques de Valdecilla”, Santander, Spain

    Carlos Ruiz-Alegria

  3. Camargo Health Center, Hospital “La Candelaria”, Tenerife, Spain

    Jesus Castillo

  4. Service of Neurology, Hospital “La Candelaria”, Tenerife, Spain

    Fernando Monton & Nuria Ruiz-Lavilla

Authors
  1. Agustin Oterino
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  2. Jesus Castillo
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  3. Julio Pascual
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  4. Amalia Cayon
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  5. Ana Alonso
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  6. Carlos Ruiz-Alegria
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  7. Natalia Valle
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  8. Fernando Monton
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  9. Nuria Ruiz-Lavilla
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Correspondence to Agustin Oterino.

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Oterino, A., Castillo, J., Pascual, J. et al. Genetic association study and meta-analysis of the HTR2C Cys23Ser polymorphism and migraine. J Headache Pain 8, 231–235 (2007). https://doi.org/10.1007/s10194-007-0399-2

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  • DOI: https://doi.org/10.1007/s10194-007-0399-2

Keywords

The Journal of Headache and Pain

ISSN: 1129-2377

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