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Rizatriptan vs. ibuprofen in migraine: a randomised placebo-controlled trial

The Journal of Headache and Pain volume 8, pages 175–179 (2007)Cite this article

Abstract

The objective of this study was to compare the efficacy of rizatriptan and ibuprofen in migraine. The study was a randomised placebo-controlled trial in a tertiary care teaching hospital. Migraine patients with <8 attacks/months were included. One hundred and fifty-five migraine patients were randomised to rizatriptan 10 mg (53), ibuprofen 400 mg (52) and placebo (50). Efficacy was assessed by headache relief, and headache freedom at 2 h and 24 h. Two-hour headache relief, was noted in 73% in rizatriptan, 53.8% in ibuprofen and 8% in placebo groups. Headache freedom was achieved in 37.7% in rizatriptan, 30.8% in ibuprofen and 2% in placebo groups. Rizatriptan was superior to ibuprofen and placebo in relieving headache at 2 h but not at 24 h. Side effects were noted in 9 patients in rizatriptan, 8 in ibuprofen and 3 in placebo, all of which were nonsignificant. Rizatriptan and ibuprofen are superior to placebo. Rizatriptan is superior to ibuprofen in relieving headache, associated symptoms and functional disability.

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Authors and Affiliations

  1. Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow, 226014, India

    Usha Kant Misra, Jayantee Kalita & Rama Kant Yadav

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  1. Usha Kant Misra
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  2. Jayantee Kalita
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  3. Rama Kant Yadav
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Correspondence to Usha Kant Misra.

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Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License ( https://creativecommons.org/licenses/by-nc/2.0 ), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Misra, U.K., Kalita, J. & Yadav, R.K. Rizatriptan vs. ibuprofen in migraine: a randomised placebo-controlled trial. J Headache Pain 8, 175–179 (2007). https://doi.org/10.1007/s10194-007-0386-7

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  • DOI: https://doi.org/10.1007/s10194-007-0386-7

Keywords

The Journal of Headache and Pain

ISSN: 1129-2377

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