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Warfarin as a therapeutic option in the control of chronic cluster headache: a report of three cases

Abstract

Chronic cluster headache remains refractory to medical therapy in at least 30% of those who suffer from this condition. The lack of alternative medical therapies that are as effective as, or more effective than, lithium carbonate makes new therapies necessary for this highly disabling condition. Based on a previous report, we gave oral anticoagulants to three patients with chronic cluster headache. Two of them remained cluster headachefree while taking warfarin. In the third patient, the use of warfarin for three weeks initially increased the frequency and intensity of cluster headache attacks but subsequently induced a prolonged remission. In spite of the paucity of data available, oral anticoagulation appears to be a promising therapy for chronic cluster headache.

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Correspondence to P. A. Kowacs.

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Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License ( https://creativecommons.org/licenses/by-nc/2.0 ), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Kowacs, P.A., Piovesan, E.J., de Campos, R.W.G.R. et al. Warfarin as a therapeutic option in the control of chronic cluster headache: a report of three cases. J Headache Pain 6, 417–419 (2005). https://doi.org/10.1007/s10194-005-0234-6

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  • DOI: https://doi.org/10.1007/s10194-005-0234-6

Key words

  • Cluster headache
  • Chronic cluster headache
  • Cluster headache therapy
  • Oral anticoagulants
  • Warfarin