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Association between migraine and HLA–DRB1 gene polymorphisms

The Journal of Headache and Pain volume 6, pages185–187(2005)Cite this article

Abstract

We examined the distribution of HLA–DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA–DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients. We conclude that, in Italian patients, migraine is associated with different alleles of the HLA–DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region.

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Affiliations

  1. Neurology III—Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15, I-10126, Turin, Italy

    I. Rainero, E. Rubino, C. Rivoiro, W. Valfrè, S. Gallone, L. Savi, S. Gentile, R. Lo Giudice, P. De Martino & L. Pinessi

  2. Transplantation Immunology, San Giovanni Battista Hospital of Turin, Turin, Italy

    E. Fasano & A. M. Dall’Omo

Authors
  1. I. Rainero
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  2. E. Fasano
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  3. E. Rubino
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  4. C. Rivoiro
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  5. W. Valfrè
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  6. S. Gallone
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  7. L. Savi
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  8. S. Gentile
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  9. R. Lo Giudice
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  10. P. De Martino
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  11. A. M. Dall’Omo
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  12. L. Pinessi
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Corresponding author

Correspondence to I. Rainero.

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Cite this article

Rainero, I., Fasano, E., Rubino, E. et al. Association between migraine and HLA–DRB1 gene polymorphisms. J Headache Pain 6, 185–187 (2005). https://doi.org/10.1007/s10194-005-0180-3

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Key words

  • HLA–DRB1
  • Migraine
  • Aura
  • Major histocompatibility complex
  • MHC

The Journal of Headache and Pain

ISSN: 1129-2377

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