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  • Genetics
  • Open Access

Association between migraine and HLA–DRB1 gene polymorphisms

  • 1Email author,
  • 2,
  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 2 and
  • 1
The Journal of Headache and Pain20056:180

https://doi.org/10.1007/s10194-005-0180-3

  • Published:

Abstract

We examined the distribution of HLA–DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA–DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients. We conclude that, in Italian patients, migraine is associated with different alleles of the HLA–DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region.

Key words

  • HLA–DRB1
  • Migraine
  • Aura
  • Major histocompatibility complex
  • MHC

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