Skip to main content

The effect of placebo and neurophysiological involvements


Placebo and placebo effect are important issues related to the drug therapy for clinical and scientific meanings. The rates of placebo may get as many as 50% for analgesic drugs in headache. The high answer to placebo brings questions on pathophysiology of headache. Answers may offer a new strategy in the implementation of trials and new insight in neurophysiology of headache. Current knowledge on placebo and placebo effect will be analysed and dicussed looking for new direction in headache field.

Author information



Corresponding author

Correspondence to Vincenzo Guidetti.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Galli, F., Riccio, B. & Guidetti, V. The effect of placebo and neurophysiological involvements. J Headache Pain 5, s74–s77 (2004).

Download citation

Key words

  • Placebo
  • Headache
  • Migraine
  • Treatment
  • Drug therapy