- ENRICO GREPPI AWARD
Heritability of migraine as a function of definition
The Journal of Headache and Pain volume 5, pages 171–176 (2004)
The objective was to examine the main genetic and environmental architecture of migraine in the Screening Across Lifetime of Twin (SALT) Study as a function of definition. We performed a quantitative genetic study of the Swedish population and a total of 12,095 twin pairs aged 41–64 years were interviewed on the telephone by trained lay personnel using a structured questionnaire. Lifetime assessment of recurrent headache and two measures of migraine were obtained, diagnosis in line with the 1988 International Headache Society criteria and self-report. The lifetime prevalence was 10.3% for diagnosed and 21.4% for self-reported migraine. Among diagnosed cases 82.3% self-reported migraine. Among self-ascertained cases, 60.3% did not fulfil diagnostic criteria, and one third had not had recurrent headache. In multivariate analyses, genetic influences were common to diagnosed and self-reported migraine (42%) and specific to self-report migraine (11%). In univariate analyses, heritability was stable (52%) when “false positives” were removed from the case definition (diagnosed or self-reported migraine) and decreased the prevalence from 23 to 16% but dropped (from 52 to 38%) when “false negatives” were removed and decreased the prevalence from 23 to 17%. A relationship between the definition and the heritability of migraine was demonstrated and phenotypes of clinical and aetiologic relevance were disclosed.
About this article
Cite this article
Svensson, D.A., Waldenlind, E., Ekbom, K. et al. Heritability of migraine as a function of definition. J Headache Pain 5, 171–176 (2004). https://doi.org/10.1007/s10194-004-0096-8
- Twin study