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Successful treatment of indomethacin-intolerant chronic paroxysmal hemicrania: report of two cases

Abstract

Chronic paroxysmal hemicrania (CPH) is a rare headache syndrome resulting in non-remitting, recurrent, intense, short-lasting pain, with typical, often total, responsiveness to indomethacin. Other drugs have anecdotally been reported to be potentially effective. Apparent unreponsiveness, in fact due to intolerance to this non-steroidal antiinflammatory drug, can lead to doubt about the initial diagnosis. Two such cases of CPH, for whom effective alternative treatment was eventually given, are described.

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Correspondence to Yusuf A. Rajabally.

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Rajabally, Y.A. Successful treatment of indomethacin-intolerant chronic paroxysmal hemicrania: report of two cases. J Headache Pain 4, 168–170 (2003). https://doi.org/10.1007/s10194-003-0053-6

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Key words

  • Chronic paroxysmal hemicrania
  • Indomethacin
  • Carbamazepine
  • Verapamil
  • Ketoprofen