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  • Open Access

Successful treatment of indomethacin-intolerant chronic paroxysmal hemicrania: report of two cases

The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches4:53

  • Received: 23 May 2003
  • Accepted: 17 July 2003


Chronic paroxysmal hemicrania (CPH) is a rare headache syndrome resulting in non-remitting, recurrent, intense, short-lasting pain, with typical, often total, responsiveness to indomethacin. Other drugs have anecdotally been reported to be potentially effective. Apparent unreponsiveness, in fact due to intolerance to this non-steroidal antiinflammatory drug, can lead to doubt about the initial diagnosis. Two such cases of CPH, for whom effective alternative treatment was eventually given, are described.

Key words

  • Chronic paroxysmal hemicrania
  • Indomethacin
  • Carbamazepine
  • Verapamil
  • Ketoprofen


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