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  • Open Access

Screening for genetic and acquired thrombophilia in a cohort of young migrainous patients

  • Bianca Bassi1,
  • Emilia Parodi2,
  • Maria Messina3,
  • Patrizia Boffi1,
  • Barbara Bobba1,
  • Maria Francesca Campagnoli2,
  • Roberto Rigardetto1 and
  • Paola Saracco2Email author
The Journal of Headache and PainOfficial Journal of the Italian Society for the Study of Headaches4:48

Received: 31 October 2002

Accepted: 17 February 2003


Growing evidence suggests a possible relationship between migraine and thrombotic risk factors. The aim of this study was to analyze the possible relationship between migraine and acquired and genetic thrombophilia in a young population. We compared 16 migrainous adolescents, 12 children with tension-type headache, and controls in terms of frequencies of prothrombotic polymorphisms (factor V Leiden, C677T mutation of 5,10 methylenetetrahydrofolate reductase, G20210A mutation of prothrombin), platelet aggregability, anticoagulant antibodies, blood lipid pattern, serum folate and vitamin B12 levels, homocysteinemia, coagulation parameters, and family history for migraine and precocious thrombotic events. This study confirms the link between migraine and increased platelet responsiveness. Overall, 62.5% of migrainous patients carried at least three thrombophilic factors. Our preliminary data suggest that, in order to assess prevention strategies, it could be appropriate to perform a complete thrombophilia screening in young patients suffering from migraine and with a family history of thrombosis.

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