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Mathematic models of migraine

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Abstract

This article describes the mathematical process of building a model of migraine syndrome guided by research data and evidences. The paper illustrates the construction of a new possible model of the evolution, in the time, of migraine. The model is an artificial network using cost-effective, conventional pure and mixed mathematical methods. It can enable to reconstruct the rules needed to give homogeneity to an incomplete data set on which we require a correct prediction and reproduction. Such a methodology represents an attempt to offer a complete output model consisting of a virtual, complex structure capable of simultaneously taking into account sparse and apparently incongruent evidences of a complex disease such as migraine. This is a model that addresses the complex rules aand relationships among inherited hyperalgesia, migraine stemming off and its further worsening. Such a construction is needed as a platform for any further artificial, non-linear neural network.

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Correspondence to Maria Nicolodi.

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Nicolodi, M., Sicuteri†, F. Mathematic models of migraine. J Headache Pain 4, 57–61 (2003) doi:10.1007/s10194-003-0031-z

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Key words

  • Migraine
  • Experimental model
  • Maths
  • Wohler curve
  • Genetic abnormality
  • Crack propagation

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