Skip to main content


Mathematic models of migraine

Article metrics

  • 215 Accesses


This article describes the mathematical process of building a model of migraine syndrome guided by research data and evidences. The paper illustrates the construction of a new possible model of the evolution, in the time, of migraine. The model is an artificial network using cost-effective, conventional pure and mixed mathematical methods. It can enable to reconstruct the rules needed to give homogeneity to an incomplete data set on which we require a correct prediction and reproduction. Such a methodology represents an attempt to offer a complete output model consisting of a virtual, complex structure capable of simultaneously taking into account sparse and apparently incongruent evidences of a complex disease such as migraine. This is a model that addresses the complex rules aand relationships among inherited hyperalgesia, migraine stemming off and its further worsening. Such a construction is needed as a platform for any further artificial, non-linear neural network.

Author information

Correspondence to Maria Nicolodi.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nicolodi, M., Sicuteri†, F. Mathematic models of migraine. J Headache Pain 4, 57–61 (2003) doi:10.1007/s10194-003-0031-z

Download citation

Key words

  • Migraine
  • Experimental model
  • Maths
  • Wohler curve
  • Genetic abnormality
  • Crack propagation


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.