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  1. Neuroanatomical alterations have been associated with cognitive deficits in mild traumatic brain injury (MTBI). However, most studies have focused on the abnormal gray matter volume in widespread brain regions...

    Authors: Hui Xu, Cheng Xu, Pengpeng Gu, Yike Hu, Yunyu Guo and Guanghui Bai
    Citation: The Journal of Headache and Pain 2023 24:43
  2. Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache response...

    Authors: Bianca N. Mason, Shayne N. Hassler, Kathryn DeFea, Scott Boitano, Josef Vagner, Theodore J. Price and Greg Dussor
    Citation: The Journal of Headache and Pain 2023 24:42
  3. Migraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis. Our aim was to evaluate the ech...

    Authors: Dolores Vilas, Sara Rubio, Mireia Gea, Jose Rios, Lourdes Ispierto, María Hernández-Pérez, Martí Paré, Mònica Millán and Laura Dorado
    Citation: The Journal of Headache and Pain 2023 24:41
  4. The Migraine in Poland study is the first large scale nationwide cross-sectional online survey of symptoms, approaches to management, treatment patterns, quality of life, and sociodemographic characteristics o...

    Authors: Marta Waliszewska-Prosół, Marcin Straburzyński, Ewa K. Czapińska-Ciepiela, Magdalena Nowaczewska, Anna Gryglas-Dworak and Sławomir Budrewicz
    Citation: The Journal of Headache and Pain 2023 24:40
  5. The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis.

    Authors: Christian Lampl, Jan Versijpt, Faisal Mohammad Amin, Christina I. Deligianni, Raquel Gil-Gouveia, Tanvir Jassal, Antoinette MaassenVanDenBrink, Raffaele Ornello, Jakob Paungarttner, Margarita Sanchez-del-Rio, Uwe Reuter, Derya Uluduz, Tessa de Vries, Dena Zeraatkar and Simona Sacco
    Citation: The Journal of Headache and Pain 2023 24:39
  6. Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide...

    Authors: Adriana Della Pietra, Georgii Krivoshein, Konstantin Ivanov, Raisa Giniatullina, Henna-Kaisa Jyrkkänen, Ville Leinonen, Marko Lehtonen, Arn M. J. M. van den Maagdenberg, Juha Savinainen and Rashid Giniatullin
    Citation: The Journal of Headache and Pain 2023 24:38
  7. The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement n...

    Authors: Bernadett Tuka, Tamás Körtési, Nikolett Nánási, Ferenc Tömösi, Tamás Janáky, Dániel Veréb, Délia Szok, János Tajti and László Vécsei
    Citation: The Journal of Headache and Pain 2023 24:35
  8. Headache disorders are not only among the most prevalent, they are also among the most disabling disorders worldwide. This paper investigates the association between headache impact on daily life and the socio...

    Authors: Britta Müller, Charly Gaul, Olaf Reis, Tim P. Jürgens, Peter Kropp, Ruth Ruscheweyh, Andreas Straube, Elmar Brähler, Stefanie Förderreuther, Jennifer Schroth and Thomas Dresler
    Citation: The Journal of Headache and Pain 2023 24:37
  9. The role of inflammation and cytokines in the pathophysiology of primary headache disorders is uncertain. We performed a systematic review and meta-analysis to synthesise the results of studies comparing perip...

    Authors: Abdu Kisekka Musubire, Sanjay Cheema, Jason C. Ray, Elspeth J. Hutton and Manjit Matharu
    Citation: The Journal of Headache and Pain 2023 24:36
  10. In the study by Johnston et al., gepants were meant to be taken to treat emergent migraine. It is tempting to speculate what the effect would be if patients were instructed to take a gepant as needed (PRN) or ...

    Authors: Andreas R. Gantenbein and Andreas Kleinschmidt
    Citation: The Journal of Headache and Pain 2023 24:33
  11. Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully understood. Besides the role of inflammatory mediators that interact with the trigeminovascular system, cyclic fluctuat...

    Authors: Anna K. Szewczyk, Samiye Ulutas, Tülin Aktürk, Linda Al-Hassany, Corinna Börner, Federica Cernigliaro, Michalis Kodounis, Salvatore Lo Cascio, David Mikolajek, Dilara Onan, Chiara Ragaglini, Susanna Ratti, Eduardo Rivera-Mancilla, Sofia Tsanoula, Rafael Villino, Karl Messlinger…
    Citation: The Journal of Headache and Pain 2023 24:31
  12. To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥ 8 days/month) or chronic migraine (CM: ≥ 15 days/month)...

    Authors: Piero Barbanti, Gabriella Egeo, Cinzia Aurilia, Paola Torelli, Cinzia Finocchi, Florindo d’Onofrio, Luigi d’Onofrio, Renata Rao, Stefano Messina, Laura Di Clemente, Angelo Ranieri, Massimo Autunno, Giuliano Sette, Bruno Colombo, Antonio Carnevale, Marco Aguggia…
    Citation: The Journal of Headache and Pain 2023 24:30
  13. Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 2...

    Authors: Jiahui He, Mengting Zhou, Fanglin Zhao, Hongrong Cheng, Hao Huang, Xiaopei Xu, Jian Han, Wenwu Hong, Faming Wang, Yujin Xiao, Jinjin Xia and Kaiming Liu
    Citation: The Journal of Headache and Pain 2023 24:28
  14. The study was designed to explore the correlation of the asymmetric regulation between periaqueductal gray (PAG) and bilateral trigeminal nucleus caudalis (TNC) in migraine rats through studying the changes of...

    Authors: Zhijian Cao, Wenjing Yu, Luping Zhang, Jiajia Yang, Jiafei Lou, Maosheng Xu and Zhengxiang Zhang
    Citation: The Journal of Headache and Pain 2023 24:27
  15. Current methods to evaluate the severity of cerebral venous sinus thrombosis (CVST) lack patient-specific indexes. Herein, a novel scoring method was investigated to estimate the thrombus burden and the intrac...

    Authors: Zhongao Wang, Chaitu Dandu, Yibing Guo, Meini Gao, Duo Lan, Liqun Pan, Da Zhou, Yuchuan Ding, Xunming Ji and Ran Meng
    Citation: The Journal of Headache and Pain 2023 24:29
  16. The goal of this observational, open-label, cohort study was to determine whether prophylactic migraine treatment with galcanezumab, a peripherally acting drug, alters the incidence of premonitory symptoms, an...

    Authors: Sait Ashina, Agustin Melo-Carrillo, Ajayi Toluwanimi, Nicolas Bolo, Edina Szabo, David Borsook and Rami Burstein
    Citation: The Journal of Headache and Pain 2023 24:26
  17. Appropriate and timely diagnosis is one of the most important milestones in effective migraine care and is affected by public awareness, access to medical care, health care systems, and physicians’ knowledge. ...

    Authors: Ido Peles, Mohnnad Asla, Mariya Abayev, Michal Gordon, Ali Alhoashle, Victor Novack, Rinat Ribalov, Tamar Lengil, Ron Maor, Mayera Elizur and Gal Ifergane
    Citation: The Journal of Headache and Pain 2023 24:25
  18. Headaches are frequent neurological disorders that are yet to be unveiled and treated comprehensively worldwide. Bearing in mind that the distribution of headache subtypes in neurology clinics (NC) is essentia...

    Authors: H. Genc, B. Baykan, H. Bolay, D. Uluduz, I. Unal-Cevik, N. Kissani, O. Luvsannorov, M. Togha, A. A. Ozdemir and A. Ozge
    Citation: The Journal of Headache and Pain 2023 24:24
  19. Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) are a favourable option for patients with migraine who experience distressful headache disability and fail to respond to traditional preven...

    Authors: Keiko Ihara, Seiya Ohtani, Narumi Watanabe, Nobuyuki Takahashi, Naoki Miyazaki, Kei Ishizuchi, Satoko Hori, Ryo Takemura, Jin Nakahara and Tsubasa Takizawa
    Citation: The Journal of Headache and Pain 2023 24:23
  20. Authors: Faisal Mohammad Amin, Roberto De Icco, Mohammad Al-Mahdi Al-Karagholi, Jayachandra M. Raghava, Frauke Wolfram, Henrik B. W. Larsson and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:22

    The original article was published in The Journal of Headache and Pain 2021 22:98

  21. In order to pursue its purpose of reducing the global burden of headache, the Global Campaign against Headache has gathered data on headache-attributed burden from countries worldwide. These data, from the ind...

    Authors: Timothy J. Steiner, Andreas Husøy, Hallie Thomas and Lars Jacob Stovner
    Citation: The Journal of Headache and Pain 2023 24:21
  22. To explore the possibility of further dividing migraine without aura (MWA), 1444 female patients fulfilled the criterion were recruited, and grouped basing on the association of MWA onset with menarche and chi...

    Authors: Xiaolin Wang, Weinan Na, Ying Yang, Wenwen Zhang, Junxia Zhao, Tingting Zhang, Yuanji Zhou, Hua Liu, Dong Zhao and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:20
  23. Headache during hemodialysis (HDH) is prevalent but not negligible. Despite the high prevalence of dialysis headaches, they have rarely been studied. Therefore, this study aimed to evaluate the prevalence, ris...

    Authors: Ying Yang, Fanchao Meng, Hanyu Zhu, Lei Zhang, Guangshuang Lu, Shaobo Xiao, Jiaji He, Shengyuan Yu and Ruozhuo Liu
    Citation: The Journal of Headache and Pain 2023 24:19
  24. Clinical trials and real-world studies revealed a spectrum of response to CGRP(-receptor) monoclonal antibodies (mAbs) in migraine prophylaxis, ranging from no effect at all to total migraine freedom. In this ...

    Authors: Bianca Raffaelli, Mira Fitzek, Lucas H. Overeem, Elisabeth Storch, Maria Terhart and Uwe Reuter
    Citation: The Journal of Headache and Pain 2023 24:16
  25. Worldwide, far from all of those who would benefit make use of headache services, largely because of clinical, social, and political barriers to access. Identifying the factors contributing to low healthcare u...

    Authors: Thien Phu Do, Mikala Dømgaard, Simon Stefansen, Timothy J. Steiner and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:18
  26. To examine whether white matter hyperintensities (WMHs) and cerebral microbleeds (CMBs) are more prevalent in people with persistent post-traumatic headache attributed to mild traumatic brain injury (TBI), com...

    Authors: Håkan Ashina, Rune H. Christensen, Haidar Muhsen Al-Khazali, Afrim Iljazi, Daniel Tolnai, Anna K. Eigenbrodt, Henrik B. W. Larsson, Henrik W. Schytz, Ulrich Lindberg and Faisal Mohammad Amin
    Citation: The Journal of Headache and Pain 2023 24:15
  27. New daily persistent headache (NPDH) is a rare primary headache that is highly disabling. The pathophysiology of NDPH is still unclear, and we aimed to reveal the underlying mechanism of NDPH through functiona...

    Authors: Xueyan Zhang, Wei Wang, Xiaoyan Bai, Yanliang Mei, Hefei Tang, Ziyu Yuan, Xue Zhang, Zhiye Li, Peng Zhang, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang
    Citation: The Journal of Headache and Pain 2023 24:14
  28. This study aimed to combine voxel-based morphometry, deformation-based morphometry, and surface-based morphometry to analyze gray matter volume and cortex shape in classical trigeminal neuralgia patients.

    Authors: Xiuhong Ge, Luoyu Wang, Lei Pan, Haiqi Ye, Xiaofen Zhu, Sandra Fan, Qi Feng, Quan Du, Wenhua Yu and Zhongxiang Ding
    Citation: The Journal of Headache and Pain 2023 24:17
  29. The changes in resting-state functional networks and their correlations with clinical traits remain to be clarified in migraine. Here we aim to investigate the brain spatio-temporal dynamics of resting-state n...

    Authors: Yan Zhou, Liusheng Gong, Yushu Yang, Linjie Tan, Lili Ruan, Xiu Chen, Hua Luo and Jianghai Ruan
    Citation: The Journal of Headache and Pain 2023 24:13
  30. Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with her...

    Authors: Lou Grangeon, Kristin Sophie Lange, Marta Waliszewska-Prosół, Dilara Onan, Karol Marschollek, Wietse Wiels, Petr Mikulenka, Fatemeh Farham, Cédric Gollion and Anne Ducros
    Citation: The Journal of Headache and Pain 2023 24:12
  31. Several studies have described potential microRNA (miRNA) biomarkers associated with migraine, but studies are scarcely reproducible primarily due to the heterogeneous variability of participants. Increasing e...

    Authors: V. J. Gallardo, J. B. Gómez-Galván, L. Asskour, M. Torres-Ferrús, A. Alpuente, E. Caronna and P. Pozo-Rosich
    Citation: The Journal of Headache and Pain 2023 24:11
  32. Migraine is a disabling neurological disorder with the pathophysiology yet to be understood. The microstructural alteration in brain white matter (WM) has been suggested to be related to migraine in recent stu...

    Authors: Lei Zhao, Wenhui Zhao, Jin Cao and Yiheng Tu
    Citation: The Journal of Headache and Pain 2023 24:10
  33. Migraine prophylactic therapy has changed over recent years with the development and approval of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway. As new therapies emer...

    Authors: Linda Al-Hassany, Hannah S. Lyons, Deirdre M. Boucherie, Fatemeh Farham, Kristin S. Lange, Karol Marschollek, Dilara Onan, Umberto Pensato, Elisabeth Storch, Angelo Torrente, Marta Waliszewska-Prosół and Uwe Reuter
    Citation: The Journal of Headache and Pain 2023 24:9
  34. Headache is the most prevalent neurological manifestation in adults and one of the leading causes of disability worldwide. In children and adolescents, headaches are arguably responsible for a remarkable impac...

    Authors: Agnese Onofri, Umberto Pensato, Chiara Rosignoli, William Wells-Gatnik, Emily Stanyer, Raffaele Ornello, Hui Zhou Chen, Federico De Santis, Angelo Torrente, Petr Mikulenka, Gabriele Monte, Karol Marschollek, Marta Waliszewska-Prosół, Wietse Wiels, Deirdre M. Boucherie, Dilara Onan…
    Citation: The Journal of Headache and Pain 2023 24:8
  35. In an earlier paper, we examined the relationship between headache-attributed disability, measured as proportion of time in ictal state, and lost productivity. In a linear model, we found positive and signific...

    Authors: Andreas Husøy, Zaza Katsarava and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2023 24:7
  36. Chronic headaches and sports-related concussions are among the most common neurological morbidities in adolescents and young adults. Given that the two can overlap in presentation, studying the effects of one ...

    Authors: Muhammad Ali, Nek Asghar, Theodore Hannah, Alexander J Schupper, Adam Li, Nickolas Dreher, Muhammad Murtaza-Ali, Vikram Vasan, Zaid Nakadar, Husni Alasadi, Anthony Lin, Eugene Hrabarchuk, Addison Quinones, Lily McCarthy, Zerubabbel Asfaw, Jonathan Dullea…
    Citation: The Journal of Headache and Pain 2023 24:6
  37. Many migraine patients do not respond adequately to conventional preventive treatments and are therefore described as treatment/medically resistant or difficult to treat cases. Calcitonin gene-related peptide ...

    Authors: Emma Troy, Arif A. Shrukalla, Alina Buture, Katie Conaty, Esther Macken, Roisin Lonergan, Jane Melling, Niamh Long, Eamonn Shaikh, Kieran Birrane, Esther M. Tomkins, Peter J. Goadsby and Martin H. Ruttledge
    Citation: The Journal of Headache and Pain 2023 24:5
  38. While new genetic analysis methods are widely used in the clinic, few researchers have focused on trigeminal neuralgia (TN) with familial clustering (≥ 2 TN patients in one kindred family). Previous literature...

    Authors: Anni Wang, Zimu Song, Xu Zhang, LiFei Xiao, Yan Feng, Chong Qi, Guohuan Zhang, Jinbo Bai, Yang Liu, Tao Sun, Fangang Meng and Feng Wang
    Citation: The Journal of Headache and Pain 2023 24:4
  39. Despite the pervasiveness of migraine, the underlying pathophysiological mechanisms initiating migraine attacks are far from well understood and are matter of scientific debate.

    Authors: Thien Phu Do, Anders Hougaard, Greg Dussor, K. C. Brennan and Faisal Mohammad Amin
    Citation: The Journal of Headache and Pain 2023 24:3
  40. Sphenopalatine ganglion (SPG) is a peripheral structure that plays an important role in cluster headache (CH). Hence, a reliable method to measure the volume of SPG is crucial for studying the peripheral mecha...

    Authors: Jr-Wei Wu, Shu-Ting Chen, Yen-Feng Wang, Kuan-Lin Lai, Ting-Yi Chen, Shih-Pin Chen, Wei-Ta Chen and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2023 24:2
  41. Migraine is a major health burden worldwide with complex pathophysiology and multifarious underlying mechanisms. One poorly understood issue concerns the early steps in the generation of migraine pain. To eluc...

    Authors: R. Giniatullin and A. Nistri
    Citation: The Journal of Headache and Pain 2023 24:1
  42. Authors: Fumihiko Sakai, Koichi Hirata, Hisaka Igarashi, Takao Takeshima, Takeo Nakayama, Hiromi Sano, Hiroyuki Kondo, Yoshiyuki Shibasaki and Nobuyuki Koga
    Citation: The Journal of Headache and Pain 2022 23:164

    The original article was published in The Journal of Headache and Pain 2022 23:70

  43. Migraine is common among females of reproductive age (estimated prevalence:17–24%) and may be associated with reproductive health through underlying central nervous system excitability, autoimmune conditions, ...

    Authors: Holly M. Crowe, Amelia K. Wesselink, Lauren A. Wise, Susan S. Jick, Kenneth J. Rothman, Ellen M. Mikkelsen, Henrik T. Sørensen and Elizabeth E. Hatch
    Citation: The Journal of Headache and Pain 2022 23:162
  44. Authors: Andreas R. Gantenbein, Reto Agosti, Christian P. Kamm, Gunther Landmann, Niklaus Meier, Gabriele Susanne Merki-Feld, Jens A. Petersen, Heiko Pohl, Philippe Ryvlin, Christoph J. Schankin, Dragana Viceic, Chiara Zecca, Elisabeth Schäfer, Ina Meyer and Michael E. Arzt
    Citation: The Journal of Headache and Pain 2022 23:161

    The original article was published in The Journal of Headache and Pain 2022 23:142

  45. Understanding migraine epidemiology and its burden is crucial for planning health policies and interventions at the local level as well as at the global level. National policies in Israel rely on global estima...

    Authors: Ido Peles, Mohnnad Asla, Mariya Abayev, Michal Gordon, Victor Novack, Rinat Ribalov, Tamar Lengil, Ron Maor, Mayera Elizur and Gal Ifergane
    Citation: The Journal of Headache and Pain 2022 23:160
  46. Migraine involves central and peripheral nervous system mechanisms. Erenumab, an anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody with little central nervous system penetrance, is effec...

    Authors: Todd J. Schwedt, Simona Nikolova, Gina Dumkrieger, Jing Li, Teresa Wu and Catherine D. Chong
    Citation: The Journal of Headache and Pain 2022 23:159