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  1. Chronic migraine is a common and highly disabling disorder. Functional MRI has indicated that abnormal brain region activation is linked with chronic migraine. Drugs targeting the calcitonin gene-related pepti...

    Authors: Shouyi Wu, Xiao Ren, Chenlu Zhu, Wei Wang, Kaibo Zhang, Zhilei Li, Xuejiao Liu and Yonggang Wang
    Citation: The Journal of Headache and Pain 2022 23:128
    Content type: Research Published on:

  2. Migraine is a highly prevalent disorder with significant economical and personal burden. Despite the development of effective therapeutics, the causes which precipitate migraine attacks remain elusive. Clinica...

    Authors: Olivia Grech, Matilde Sassani, Gisela Terwindt, Gareth G. Lavery, Susan P. Mollan and Alexandra J. Sinclair
    Citation: The Journal of Headache and Pain 2022 23:127
    Content type: Review Published on:

  3. Migraine affects a significant fraction of the world population, yet its etiology is not completely understood. In vitro results highlighted thalamocortical and intra-cortical glutamatergic synaptic gain-of-fu...

    Authors: Nicolò Meneghetti, Chiara Cerri, Eleonora Vannini, Elena Tantillo, Angelita Tottene, Daniela Pietrobon, Matteo Caleo and Alberto Mazzoni
    Citation: The Journal of Headache and Pain 2022 23:125
    Content type: Research Published on:

  4. In disease areas with ‘soft’ outcomes (i.e., the subjective aspects of a medical condition or its management) such as migraine or depression, extraction and validation of real-world evidence (RWE) from electro...

    Authors: Nada A. Hindiyeh, Daniel Riskin, Kimberly Alexander, Roger Cady and Steven Kymes
    Citation: The Journal of Headache and Pain 2022 23:124
    Content type: Research Published on:

  5. In Italy, monoclonal antibodies targeting the CGRP pathway are subsidized for the preventive treatment of high frequency and chronic migraine (CM) in patients with a MIgraine Disability ASsessment (MIDAS) scor...

    Authors: Roberto De Icco, Gloria Vaghi, Marta Allena, Natascia Ghiotto, Elena Guaschino, Daniele Martinelli, Lara Ahmad, Michele Corrado, Federico Bighiani, Federica Tanganelli, Sara Bottiroli, Francescantonio Cammarota, Grazia Sances and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2022 23:123
    Content type: Research Published on:

  6. Chronic migraine is a common neurovascular brain disorder with substantial economic costs. We performed a systematic review to identify economic evaluations of pharmacological treatments for adults with chroni...

    Authors: Saval Khanal, Martin Underwood, Seyran Naghdi, Anna Brown, Callum Duncan, Manjit Matharu and Hema Mistry
    Citation: The Journal of Headache and Pain 2022 23:122
    Content type: Review Published on:

  7. To study the impact of chronic migraine (CM) on the cognition and quality of life (QoL) of patients in the interictal period, and to analyse the degree of reversibility of any observed alterations following th...

    Authors: Cristina González-Mingot, Anna Gil-Sánchez, Marc Canudes-Solans, Silvia Peralta-Moncusi, Maria José Solana-Moga and Luis Brieva-Ruiz
    Citation: The Journal of Headache and Pain 2022 23:121
    Content type: Research Published on:

  8. Serum levels of Calcitonin Gene-Related Peptide (CGRP)-like immunoreactivity (CGRP-LI) in migraine patients before and after starting treatment with erenumab were measured to evaluate the association with clin...

    Authors: Simone de Vries Lentsch, Ingrid M. Garrelds, A. H. Jan Danser, Gisela M. Terwindt and Antoinette MaassenVanDenBrink
    Citation: The Journal of Headache and Pain 2022 23:120
    Content type: Research Published on:

  9. The thalamus plays a crucial role in transmitting nociceptive information to various cortical regions involving migraine-related allodynia and photophobia. Abnormal structural and functional alterations relate...

    Authors: Ying Yang, Huang Xu, Ziru Deng, Wenwen Cheng, Xiuxiu Zhao, Yan Wu, Yuhua Chen, Gui Wei and Ying Liu
    Citation: The Journal of Headache and Pain 2022 23:119
    Content type: Research Published on:

  10. The Global Campaign against Headache collects data from children (6–11 years) and adolescents (12–17) to inform health and education policies and contribute to the Global Burden of Disease (GBD) study. This su...

    Authors: Nfwama Kawatu, Somwe Wa Somwe, Ornella Ciccone, Misheck Mukanzu, Derya Uluduz, Tayyar Şaşmaz, Bengü Nehir Buğdaycı Yalçın, Christian Wöber and Timothy J. Steiner
    Citation: The Journal of Headache and Pain 2022 23:118
    Content type: Research Published on:

  11. This study aimed to explore the central mechanism of classical trigeminal neuralgia (CTN) by analyzing the static amplitude of low-frequency fluctuation (sALFF) and dynamic amplitude of low-frequency fluctuati...

    Authors: Xiuhong Ge, Luoyu Wang, Lei Pan, Haiqi Ye, Xiaofen Zhu, Sandra Fan, Qi Feng, Wenhua Yu and Zhongxiang Ding
    Citation: The Journal of Headache and Pain 2022 23:117
    Content type: Research Published on:

  12. The relative effects of monoclonal antibody against calcitonin gene-related peptide (CGRP) or its receptor for adult migraine patients with prior treatment failure remains uncertain. Therefore, this study syst...

    Authors: Xing Wang, Dingke Wen, Qiang He, Chao You and Lu Ma
    Citation: The Journal of Headache and Pain 2022 23:105
    Content type: Research Published on:

  14. Patients with chronic migraine (CM) treated with eptinezumab in the PROMISE-2 trial achieved greater reductions in migraine and headache frequency, impact, and acute headache medication (AHM) use than did pati...

    Authors: Robert P. Cowan, Michael J. Marmura, Hans-Christoph Diener, Amaal J. Starling, Jack Schim, Joe Hirman, Thomas Brevig and Roger Cady
    Citation: The Journal of Headache and Pain 2022 23:115
    Content type: Research Published on:

  15. Trigeminal neuralgia is an episodic severe neuralgic pain and can be managed both medically and surgically. If possible, this should be directed by a Multidisciplinary Team (MDT) of specialised surgeons, physi...

    Authors: Sanjeet Singhota, Nana Tchantchaleishvili, Jianhua Wu, Ludvic Zrinzo, Lewis Thorne, Harith Akram and Joanna M. Zakrzewska
    Citation: The Journal of Headache and Pain 2022 23:114
    Content type: Research Published on:

  16. Migraine is a primary headache with genetic susceptibility, but the pathophysiological mechanisms are poorly understood, and it remains an unmet medical need. Earlier we demonstrated significant differences in...

    Authors: Timea Aczél, Bettina Benczik, Bence Ágg, Tamás Körtési, Péter Urbán, Witold Bauer, Attila Gyenesei, Bernadett Tuka, János Tajti, Péter Ferdinandy, László Vécsei, Kata Bölcskei, József Kun and Zsuzsanna Helyes
    Citation: The Journal of Headache and Pain 2022 23:113
    Content type: Research Published on:

  17. Migraine is the second leading cause of disability worldwide. Although many preventive treatments reduce migraine frequency and severity, it is unclear whether these treatments reduce migraine-related disabili...

    Authors: Peter McAllister, Joshua M. Cohen, Verena Ramirez Campos, Xiaoping Ning, Lindsay Janka and Steve Barash
    Citation: The Journal of Headache and Pain 2022 23:112
    Content type: Research article Published on:

  19. It is well known that the course of migraine is influenced by comorbidities and that individual psychological characteristics may impact on the disease. Proper identification of psychological factors that are ...

    Authors: Francesca Pistoia, Federico Salfi, Gennaro Saporito, Raffaele Ornello, Ilaria Frattale, Giulia D’Aurizio, Daniela Tempesta, Michele Ferrara and Simona Sacco
    Citation: The Journal of Headache and Pain 2022 23:110
    Content type: Research Published on:

  20. More than 2/3 of children and adolescents in Germany regularly suffer from headaches. Headache-related limitations in everyday life, school drop-out and educational impairment are common. Structured therapy pr...

    Authors: Hanna Sobe, Matthias Richter, Reinhard Berner, Maja von der Hagen, Antje Hähner, Ingo Röder, Thea Koch, Rainer Sabatowski, Anna Klimova and Gudrun Gossrau
    Citation: The Journal of Headache and Pain 2022 23:109
    Content type: Research Published on:

  21. Studies investigating the association between migraine and dementia have reported inconsistent findings. This study aimed to evaluate whether patients with migraine have an increased risk of dementia compared ...

    Authors: Kyungduk Hurh, Sung Hoon Jeong, Seung Hoon Kim, Suk-Yong Jang, Eun-Cheol Park and Sung-In Jang
    Citation: The Journal of Headache and Pain 2022 23:108
    Content type: Research Published on:

  22. Unlike the spontaneously appearing aura in migraineurs, experimentally, cortical spreading depression (CSD), the neurophysiological correlate of aura is induced by non-physiological stimuli. Consequently, neur...

    Authors: Sahin Hanalioglu, Aslihan Taskiran-Sag, Hulya Karatas, Buket Donmez-Demir, Sinem Yilmaz-Ozcan, Emine Eren-Kocak, Yasemin Gursoy-Ozdemir and Turgay Dalkara
    Citation: The Journal of Headache and Pain 2022 23:107
    Content type: Research Published on:

  23. Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the do...

    Authors: Cédric Gollion, Fleur Lerebours, Federico Nemmi, Germain Arribarat, Fabrice Bonneville, Vincent Larrue and Patrice Péran
    Citation: The Journal of Headache and Pain 2022 23:106
    Content type: Research Published on:

  24. Erenumab, a fully human monoclonal antibody that targets the calcitonin gene-related peptide receptor, has demonstrated efficacy and safety in the prevention of episodic and chronic migraine. There exists an u...

    Authors: Christian Lampl, Viktoria Kraus, Katrina Lehner, Brett Loop, Mahan Chehrenama, Zofia Maczynska, Shannon Ritter, Jan Klatt and Josefin Snellman
    Citation: The Journal of Headache and Pain 2022 23:104
    Content type: Research Published on:

  25. It is poorly described how often headache attributed to stroke continues for more than 3 months, i.e. fulfils the criteria for persistent headache attributed to ischemic stroke. Our aims were: 1) to determine ...

    Authors: Elena R. Lebedeva, Anton V. Ushenin, Natalia M. Gurary, Denis V. Gilev, Nadezda V. Kislyak and Jes Olesen
    Citation: The Journal of Headache and Pain 2022 23:103
    Content type: Research Published on:

  26. Whether neuroinflammation causes comorbid mood disorders in neuropathic pain remains elusive. Here we investigated the role of high mobility group box 1 protein (HMGB1), a proinflammatory cytokine, in the medi...

    Authors: Yu Du, Ceng-Lin Xu, Jie Yu, Keyue Liu, Shi-Da Lin, Ting-Ting Hu, Feng-Hui Qu, Fang Guo, Guo-Dong Lou, Masahiro Nishibori, Wei-Wei Hu, Zhong Chen and Shi-Hong Zhang
    Citation: The Journal of Headache and Pain 2022 23:102
    Content type: Research Published on:

  27. The burden of post-coronavirus disease (COVID)-19 symptoms has been increasing and is of great concern in patients with pre-existing chronic medical conditions.This study aimed to delineate the post-COVID-19 n...

    Authors: Rehab Magdy, Alaa Elmazny, Shaimaa H. Soliman, Eman H. Elsebaie, Sara H. Ali, Ali M. Abdel Fattah, Mahmoud Hassan, Ahmed Yassien, Noha A. Mahfouz, Radwa M. Elsayed, Wael Fathy, Hoda M. Abdel-Hamid, Jehan Mohamed and Mona Hussein
    Citation: The Journal of Headache and Pain 2022 23:101
    Content type: Research Published on:

  28. Migraine is a complex condition in which genetic predisposition interacts with other biological and environmental factors determining its course. A hyperresponsive brain cortex, peripheral and central alterati...

    Authors: Chiara Rosignoli, Raffaele Ornello, Agnese Onofri, Valeria Caponnetto, Licia Grazzi, Alberto Raggi, Matilde Leonardi and Simona Sacco
    Citation: The Journal of Headache and Pain 2022 23:100
    Content type: Review Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2022 23:116

  29. Photophobia, the aberrantly increased sensitivity to light, is a common symptom in migraine patients and light discomfort is frequently found as a trigger for migraine attacks. In behavioral studies, planned e...

    Authors: Eva Matt, Tuna Aslan, Ahmad Amini, Kardelen Sariçiçek, Stefan Seidel, Paul Martin, Christian Wöber and Roland Beisteiner
    Citation: The Journal of Headache and Pain 2022 23:99
    Content type: Research Published on:

  30. The pathogenesis of chronic migraine remains unresolved. Recent studies have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine. The dopamine D2 receptor, a member of G protein-co...

    Authors: Wei Zhang, Ming Lei, Qianwen Wen, Dunke Zhang, Guangcheng Qin, Jiying Zhou and Lixue Chen
    Citation: The Journal of Headache and Pain 2022 23:98
    Content type: Research Published on:

  31. Previous research has extensively documented the impact of migraine episodes (‘ictal’) on patients’ health-related quality of life. Few studies have looked at the impact of migraine on migraine-free days (‘int...

    Authors: Lena T. Hubig, Timothy Smith, Emma Williams, Lauren Powell, Karissa Johnston, Linda Harris, Gilbert L’Italien, Vladimir Coric, Andrew J. Lloyd and Siu Hing Lo
    Citation: The Journal of Headache and Pain 2022 23:97
    Content type: Research Published on:

  32. To investigate whether persistent post-traumatic headache attributed to mild traumatic brain injury (TBI) is associated with more pronounced pericranial tenderness and lower pressure pain thresholds (PPTs) in ...

    Authors: Håkan Ashina, Haidar Muhsen Al-Khazali, Afrim Iljazi, Sait Ashina, Faisal Mohammad Amin and Henrik Winther Schytz
    Citation: The Journal of Headache and Pain 2022 23:96
    Content type: Research Published on:

  33. The diagnosis of migraine is mainly clinical and self-reported, which makes additional examinations unnecessary in most cases. Migraine can be subtyped into chronic (CM) and episodic (EM). Despite the very hig...

    Authors: Javier Gomez-Pilar, Víctor Martínez-Cagigal, David García-Azorín, Carlos Gómez, Ángel Guerrero and Roberto Hornero
    Citation: The Journal of Headache and Pain 2022 23:95
    Content type: Review Published on:

  34. Authors: Saeid Safiri, Ali-Asghar Kolahi, Maryam Noori, Seyed Aria Nejadghaderi, Armin Aslani, Mark J. M. Sullman, Mehdi Farhoudi, Mostafa Araj-Khodaei, Gary S. Collins, Jay S. Kaufman and Kurosh Gharagozli
    Citation: The Journal of Headache and Pain 2022 23:94
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2022 23:77

  35. Headache is among the most frequent symptoms persisting or newly developing after coronavirus disease 2019 (COVID-19) as part of the so-called long COVID syndrome. The knowledge on long COVID headache is still...

    Authors: Claudio Tana, Enrico Bentivegna, Soo-Jin Cho, Andrea M. Harriott, David García-Azorín, Alejandro Labastida-Ramirez, Raffaele Ornello, Bianca Raffaelli, Eloísa Rubio Beltrán, Ruth Ruscheweyh and Paolo Martelletti
    Citation: The Journal of Headache and Pain 2022 23:93
    Content type: Review Published on:

  36. There have been a few studies regarding the pre-attack symptoms (PAS) and pre-episode symptoms (PES) of cluster headache (CH), but none have been conducted in the Chinese population. The purpose of this study ...

    Authors: Ke Li, Shuping Sun, Zhanyou Xue, Sufen Chen, Chunyang Ju, Dongmei Hu, Xiaoyu Gao, Yanhong Wang, Dan Wang, Jianjun Chen, Li Li, Jing Liu, Mingjie Zhang, Zhihua Jia, Xun Han, Huanxian Liu…
    Citation: The Journal of Headache and Pain 2022 23:92
    Content type: Consensus Article Published on:

  37. The benefits of preventive treatment on the effectiveness of migraine management have rarely been examined. This post hoc analysis investigated the impact of eptinezumab on the optimization of acute medication...

    Authors: Roger Cady, Richard B. Lipton, Dawn C. Buse, Mette Krog Josiassen, Annika Lindsten and Anders Ettrup
    Citation: The Journal of Headache and Pain 2022 23:91
    Content type: Research Published on:

  38. Galcanezumab, a humanized monoclonal antibody that binds calcitonin gene-related peptide, has demonstrated efficacy and good tolerability in patients with episodic migraine in previous phase 3 trials. We repor...

    Authors: Bo Hu, Gang Li, Xiaohong Li, Shan Wu, Tingmin Yu, Xiang Li, Hongru Zhao, Zhihua Jia, Junpeng Zhuang and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2022 23:90
    Content type: Research Published on:

  39. The aim of the study was to investigate whether MwoA and MwA are different manifestations of a single disease, distinct clinical entities, or located at two poles of a spectrum.

    Authors: Ye Ran, Ziming Yin, Yajun Lian, Yanmei Xu, Yajie Li, Jiale Liu, Qun Gu, Fanhong Yan, Zhaoli Ge, Yu Lian, Dongmei Hu, Sufen Chen, Yangyang Wang, Xiaolin Wang, Rongfei Wang, Xiaoyan Chen…
    Citation: The Journal of Headache and Pain 2022 23:89
    Content type: Research Published on:

  40. Previous studies revealed inconsistent results regarding association between migraine and cognitive impairment. In addition, previous studies found inconsistent results regarding the association between migrai...

    Authors: Lihua Gu, Yanjuan Wang and Hao Shu
    Citation: The Journal of Headache and Pain 2022 23:88
    Content type: Research Published on:

  41. The onset and duration of spontaneous migraine attacks are most often difficult to predict which, in turn, makes it challenging to study the neurobiologic underpinnings of the disease in a controlled experimen...

    Authors: Håkan Ashina, Rune Häckert Christensen and Messoud Ashina
    Citation: The Journal of Headache and Pain 2022 23:87
    Content type: Review Published on:

  42. Calcitonin gene-related peptide (CGRP) inhibitors have been developed as options for treatment of chronic and episodic migraine. We present our experience of the use of erenumab in a tertiary headache centre.

    Authors: Michael Lowe, Lesley Murray, Alok Tyagi, George Gorrie, Sarah Miller and Krishna Dani
    Citation: The Journal of Headache and Pain 2022 23:86
    Content type: Research Published on:

  43. Headache attributed to intracranial endovascular procedures is described in the ICHD-3. Our aim was to study the frequency and characteristics of headache specifically related to thrombectomy in patients with ...

    Authors: Daniel Gallo, Leire Manrique, Marcos Polanco, Andrés González-Mandly, Eduardo Torres, Enrique Palacio, José Luis Vázquez, Sara Pérez-Pereda, Vicente González-Quintanilla, Jorge Madera and Julio Pascual
    Citation: The Journal of Headache and Pain 2022 23:85
    Content type: Research Published on:

  44. Large numbers of people with headache who would benefit are not reached by headache services. Among the causes are poor or disorganized provision of headache services, but reluctance to seek healthcare has fre...

    Authors: Thien Phu Do, Simon Stefansen, Mikala Dømgaard, Timothy J. Steiner and Messoud Ashina
    Citation: The Journal of Headache and Pain 2022 23:84
    Content type: Research Published on:

  45. The pathogenesis of migraine chronification remains unclear. Functional and structural magnetic resonance imaging studies have shown impaired functional and structural alterations in the brains of patients wit...

    Authors: Wei Wang, Xueyan Zhang, Xiaoyan Bai, Yingkui Zhang, Ziyu Yuan, Hefei Tang, Zhiye Li, Zhangxuan Hu, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang
    Citation: The Journal of Headache and Pain 2022 23:83
    Content type: Research Published on:

  46. Authors: Ruth Ruscheweyh, Theresa Klonowski, Gudrun Goßrau, Torsten Kraya, Charly Gaul, Andreas Straube, Tim Patrick Jürgens, Jörg Scheidt and Stefanie Förderreuther
    Citation: The Journal of Headache and Pain 2022 23:82
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2022 23:74

  47. Sensitization to sensory stimuli is an essential feature of migraine attacks. The relationship between the clinical course of migraine and increased sensitivity to olfactory stimuli has been little studied so ...

    Authors: Gudrun Gossrau, Marie Frost, Anna Klimova, Thea Koch, Rainer Sabatowski, Coralie Mignot and Antje Haehner
    Citation: The Journal of Headache and Pain 2022 23:81
    Content type: Research Published on:

  48. Several functional neuroimaging studies on healthy controls and patients with migraine with aura have shown that the activation of functional networks during visual stimulation is not restricted to the striate...

    Authors: Gianluca Coppola, Ilenia Corbelli, Antonio Di Renzo, Andrea Chiappiniello, Pietro Chiarini, Vincenzo Parisi, Giorgio Guercini, Paolo Calabresi, Roberto Tarducci and Paola Sarchielli
    Citation: The Journal of Headache and Pain 2022 23:80
    Content type: Research Published on:

  49. Targeting fatty acid amide hydrolase (FAAH) is a promising therapeutic strategy to combat certain forms of pain, including migraine headache. FAAH inhibitors, such as the O-biphenyl-3-yl carbamate URB597, have be...

    Authors: Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Miriam Francavilla, Angelo Reggiani, Natalia Realini, Rita Scarpelli, Daniele Piomelli and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2022 23:79
    Content type: Research Published on:

  50. Migraine represents a serious burden for national health systems. However, preventive treatment is not optimally applied to reduce the severity and frequency of headache attacks and the related expenses. Our a...

    Authors: Pablo Irimia, David García-Azorín, Mercedes Núñez, Sílvia Díaz-Cerezo, Pepa García de Polavieja, Tommaso Panni, Aram Sicras-Navarro, Antoni Sicras-Mainar and Antonio Ciudad
    Citation: The Journal of Headache and Pain 2022 23:78
    Content type: Research Published on:
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