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  1. Calcitonin gene-related peptide (CGRP) is involved in migraine pathophysiology and blood pressure regulation. Although clinical trials have established the cardio-cerebrovascular safety profile of anti-CGRP tr...

    Authors: Kaicheng Wang, Brenda T. Fenton, Vinh X. Dao, Alexander B. Guirguis, Sarah E. Anthony, Melissa Skanderson and Jason J. Sico
    Citation: The Journal of Headache and Pain 2023 24:108
    Content type: Research Published on:

  2. Authors: Adrian Scutelnic, Hristina Drangova, Antonia Klein, Nedelina Slavova, Morin Beyeler, Julian Lippert, Norbert Silimon, Thomas R. Meinel, Marcel Arnold, Urs Fischer, Franz Riederer, Heinrich P. Mattle, Simon Jung and Christoph J. Schankin
    Citation: The Journal of Headache and Pain 2023 24:107
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2023 24:100

  4. There is increasing evidence from human and animal studies that cortical spreading depression (CSD) is the neurophysiological correlate of migraine aura and a trigger of migraine pain mechanisms. The mechanism...

    Authors: Marina Vitale, Angelita Tottene, Maral Zarin Zadeh, KC Brennan and Daniela Pietrobon
    Citation: The Journal of Headache and Pain 2023 24:105
    Content type: Research Published on:

  5. Migraine is a cyclic, neurosensory disorder characterized by recurrent headaches and altered sensory processing. The latter is manifested in hypersensitivity to visual stimuli, measured with questionnaires and...

    Authors: Angela Marti-Marca, Adrià Vilà-Balló, Xim Cerda-Company, Nara Ikumi, Marta Torres-Ferrus, Edoardo Caronna, Victor J. Gallardo, Alicia Alpuente, Mireia Torralba Cuello, Salvador Soto-Faraco and Patricia Pozo-Rosich
    Citation: The Journal of Headache and Pain 2023 24:104
    Content type: Research Published on:

  6. The phase 3 randomized PERSIST study demonstrated the efficacy and tolerability of galcanezumab, a humanized anti-calcitonin gene-related peptide (CGRP) monoclonal antibody for prevention of episodic migraines...

    Authors: Jiying Zhou, Lianmei Zhong, Debashish Chowdhury, Kirill Skorobogatykh, Guogang Luo, Xiaosu Yang, Mingjie Zhang, Lingli Sun, Hui Liu, Chenxi Qian and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:103
    Content type: Research Published on:

  7. Individuals using onabotulinumtoxinA as a preventive migraine treatment often use acute treatments for breakthrough attacks. Data on real-world effectiveness of the small-molecule calcitonin gene–related pepti...

    Authors: Aubrey Manack Adams, Susan Hutchinson, Ella Engstrom, Nicolai D. Ayasse, Daniel Serrano, Linda Davis, Katherine Sommer, Janette Contreras-De Lama and Richard B. Lipton
    Citation: The Journal of Headache and Pain 2023 24:102
    Content type: Research Published on:

  8. To date, real-world evidence on persistence to anti-calcitonin gene-related peptide (anti-CGRP) monoclonal antibodies (mAbs) or onabotulinumtoxinA have excluded eptinezumab. This retrospective cohort study was...

    Authors: Larry Charleston IV, Brian Talon, Christine Sullivan, Carlton Anderson, Steven Kymes, Stephane A. Regnier, Seema Soni-Brahmbhatt and Stephanie J. Nahas
    Citation: The Journal of Headache and Pain 2023 24:101
    Content type: Research Published on:

  9. Given the similar presentation of migraine aura and acute ischemic stroke, advancing patient age might change the characteristics of migraine with aura (MA) and be clinically important. Clinical data, however,...

    Authors: Adrian Scutelnic, Hristina Drangova, Antonia Klein, Nedelina Slavova, Morin Beyeler, Julian Lippert, Norbert Silimon, Thomas R. Meinel, Marcel Arnold, Urs Fischer, Franz Riederer, Heinrich P. Mattle, Simon Jung and Christoph J. Schankin
    Citation: The Journal of Headache and Pain 2023 24:100
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2023 24:107

  10. The monoclonal antibodies (mAbs) blocking the calcitonin-gene related peptide (CGRP) pathway, collectively called here “anti-CGRP/rec mAbs”, have dramatically improved preventive migraine treatment. Although t...

    Authors: Jean Schoenen, Annelies Van Dycke, Jan Versijpt and Koen Paemeleire
    Citation: The Journal of Headache and Pain 2023 24:99
    Content type: Review Published on:

  11. Whether migraine is related to the risk of cardiovascular diseases (CVDs) remains unclear. Therefore, we conducted a longitudinal follow-up study to address the association between migraine and the development...

    Authors: Mi Jung Kwon, Hyo Geun Choi, Yoo Hwan Kim, Joo-Hee Kim, Hyun Taek Rim, Heui Seung Lee, Jae Keun Oh, In Bok Chang, Joon Ho Song and Ji Hee Kim
    Citation: The Journal of Headache and Pain 2023 24:98
    Content type: Research Published on:

  12. In idiopathic intracranial hypertension (IIH), certain MRI features are promising diagnostic markers, but whether these have prognostic value is currently unknown.

    Authors: Gabriel Bsteh, Wolfgang Marik, Nik Krajnc, Stefan Macher, Christoph Mitsch, Philip Pruckner, Klaus Novak, Christian Wöber and Berthold Pemp
    Citation: The Journal of Headache and Pain 2023 24:97
    Content type: Research Published on:

  13. The evidence supporting the efficacy of dietary preventive therapy in migraine is rising, particularly regarding the ketogenic diet. However, less evidence exists for the Low-Glycemic Index Diet and the 2:1 KD...

    Authors: Yan Tereshko, Simone Dal Bello, Cherubino Di Lorenzo, Sara Pez, Alice Pittino, Roberto Sartor, Francesca Filippi, Christian Lettieri, Enrico Belgrado, Riccardo Garbo, Giovanni Merlino, Gian Luigi Gigli and Mariarosaria Valente
    Citation: The Journal of Headache and Pain 2023 24:95
    Content type: Research Published on:

  15. Cortical spreading depolarization (CSD), the neurophysiological correlate of the migraine aura, can activate trigeminal pain pathways, but the neurobiological mechanisms and behavioural consequences remain unc...

    Authors: Anisa Dehghani, Maarten Schenke, Sandra H. van Heiningen, Hulya Karatas, Else A. Tolner and Arn M. J. M. van den Maagdenberg
    Citation: The Journal of Headache and Pain 2023 24:96
    Content type: Research Published on:

  16. Migraine headache attacks and accompanying sensory augmentation can be induced by several agents including levcromakalim (LVC), that is also capable of provoking aura-like symptoms in migraineurs. We investiga...

    Authors: Berkay Alpay, Bariscan Cimen, Elif Akaydin, Hayrunnisa Bolay and Yildirim Sara
    Citation: The Journal of Headache and Pain 2023 24:93
    Content type: Research Published on:

  17. Tension-type headache (TTH) and migraine are two common primary headaches distinguished by clinical characteristics according to the 3rd edition of the International Classification of Headache Disorders. Migraine...

    Authors: Dilara Onan, Samaira Younis, William David Wellsgatnik, Fatemeh Farham, Saulius Andruškevičius, Ana Abashidze, Asel Jusupova, Yuriy Romanenko, Oxana Grosu, Meerimgul Zamirbekovna Moldokulova, Ulkar Mursalova, Saida Saidkhodjaeva, Paolo Martelletti and Sait Ashina
    Citation: The Journal of Headache and Pain 2023 24:92
    Content type: Review Published on:

  18. Migraine is more prevalent in females, raising the possibility that sex and gonadal hormones modulate migraine. We recently demonstrated that minimally invasive optogenetic spreading depolarization (opto-SD) e...

    Authors: Andrea M. Harriott, Angel Waruinge, Viola Appiah-Danquah, Leah Berhanu, Andreia Morais and Cenk Ayata
    Citation: The Journal of Headache and Pain 2023 24:85
    Content type: Research Published on:

  19. Trigeminal neuralgia (TN) is a debilitating pain disorder that still lacks an ideal treatment option. Pulsed radiofrequency (PRF), especially with high output voltage, is a novel and minimally invasive techniq...

    Authors: Yitong Jia, Hao Cheng, Niti Shrestha, Hao Ren, Chunmei Zhao, Kunpeng Feng and Fang Luo
    Citation: The Journal of Headache and Pain 2023 24:91
    Content type: Research Published on:

  20. In idiopathic intracranial hypertension (IIH), sustained weight loss is the main pillar in modifying disease course, whereby glucagon-like peptide-1 receptor agonists (GLP-1-RAs) could present an attractive tr...

    Authors: Nik Krajnc, Bianca Itariu, Stefan Macher, Wolfgang Marik, Jürgen Harreiter, Martin Michl, Klaus Novak, Christian Wöber, Berthold Pemp and Gabriel Bsteh
    Citation: The Journal of Headache and Pain 2023 24:89
    Content type: Research Published on:

  22. Insights into the burden, needs and treatment of migraine from internet-based surveys in diverse real-world migraine populations are needed, especially at a time when novel preventive migraine medications are ...

    Authors: Julio Pascual, Tommaso Panni, Grazia Dell’Agnello, Saygin Gonderten, Diego Novick and Stefan Evers
    Citation: The Journal of Headache and Pain 2023 24:88
    Content type: Review Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2023 24:142

  23. The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110 years ago and has been found to play a crucial role in the development of multicellular organisms. Notch receptors and t...

    Authors: Yan Zhang, Tingting Wang, Sanlan Wu, Li Tang, Jia Wang, Jinghan Yang, Shanglong Yao and Yan Zhang
    Citation: The Journal of Headache and Pain 2023 24:87
    Content type: Review Published on:

  24. Mindfulness gained considerable attention for migraine management, but RCTs are lacking. We aimed to assess the efficacy of a six-sessions mindfulness-based treatment added to treatment as usual (TaU) in patie...

    Authors: Licia Grazzi, Domenico D’Amico, Erika Guastafierro, Greta Demichelis, Alessandra Erbetta, Davide Fedeli, Anna Nigri, Emilio Ciusani, Corso Barbara and Alberto Raggi
    Citation: The Journal of Headache and Pain 2023 24:86
    Content type: Research Published on:

  25. Tension-type headache (TTH) is the most prevalent primary headache disorder. Neck pain is commonly associated with primary headaches and the trigemino-cervical complex (TCC) refers to the convergence of trigem...

    Authors: Nico Sollmann, Paul Schandelmaier, Dominik Weidlich, Jonathan Stelter, Gabby B. Joseph, Corinna Börner, Severin Schramm, Meinrad Beer, Claus Zimmer, Mirjam N. Landgraf, Florian Heinen, Dimitrios C. Karampinos, Thomas Baum and Michaela V. Bonfert
    Citation: The Journal of Headache and Pain 2023 24:84
    Content type: Research Published on:

  26. Migraine is a very common headache disorder on the population level, characterized by symptomatic attacks (activity). For many people with migraine, the migraine symptoms intermittently or permanently cease du...

    Authors: Marco Piccininni, Ralph Brinks, Jessica L. Rohmann and Tobias Kurth
    Citation: The Journal of Headache and Pain 2023 24:83
    Content type: Research Published on:

  27. The close relationship between pain and mental health problems is well-known, and psychological intervention can provide an effective alternative to medication-based pain relief. However, previous studies on t...

    Authors: Chongjie Yao, Yuchen Zhang, Ping Lu, Bin Xiao, Pingping Sun, Jiming Tao, Yanbin Cheng, Lingjun Kong, Dongsheng Xu and Min Fang
    Citation: The Journal of Headache and Pain 2023 24:82
    Content type: Research Published on:

  28. Menstrual migraine is a subtype of migraine disease that is typically more disabling, longer-lasting, and more challenging to treat. The purpose of this network meta-analysis (NMA) is to compare the relative e...

    Authors: Han Zhang, Jian-Zhi Qi and Zhi-Hua Zhang
    Citation: The Journal of Headache and Pain 2023 24:81
    Content type: Review Published on:

  29. New daily persistent headache (NDPH) is a rare primary headache disorder characterized by daily and persistent sudden onset headaches. The pathogenesis of NDPH remains unclear, and there are few white matter i...

    Authors: Yanliang Mei, Wei Wang, Dong Qiu, Ziyu Yuan, Xiaoyan Bai, Hefei Tang, Peng Zhang, Xue Zhang, Yaqing Zhang, Xueying Yu, Binbin Sui and Yonggang Wang
    Citation: The Journal of Headache and Pain 2023 24:80
    Content type: Research Published on:

  30. The majority of epidemiological studies on migraine have been conducted in a specific country or region, and there is a lack of globally comparable data. We aim to report the latest information on global migra...

    Authors: Luying Fan, Yuhang Wu, Jiehua Wei, Fan Xia, Yufeng Cai, Senmao Zhang, Junxiang Miao, Yunzhe Zhou, Chu Liu, Wei Yan, Dan Liu, Lizhang Chen and Tingting Wang
    Citation: The Journal of Headache and Pain 2023 24:79
    Content type: Research Published on:

  31. Prior clinical studies suggest a shared mechanism between vestibular symptoms and migraine headache. However, the specific neuroanatomical substrate connecting vestibular symptoms with migraine remains to be l...

    Authors: Yun Zhang, Yixin Zhang, Yanyun Wang, Xiaoyan Zhang, Guangcheng Qin, Dunke Zhang, Lixue Chen and Jiying Zhou
    Citation: The Journal of Headache and Pain 2023 24:77
    Content type: Research Published on:

  32. Migraine is a common and complex neurological disease potentially caused by a polygenic interaction of multiple gene variants. Many genes associated with migraine are involved in pathways controlling the synap...

    Authors: Daniela Felício, Andreia Dias, Sandra Martins, Estefânia Carvalho, Alexandra M. Lopes, Nádia Pinto, Carolina Lemos, Mariana Santos and Miguel Alves-Ferreira
    Citation: The Journal of Headache and Pain 2023 24:78
    Content type: Brief Report Published on:

  33. Migraine is a disabling and chronic neurovascular headache disorder. Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a pivotal role in the pathogenesis of migraine. Th...

    Authors: Linda Al-Hassany, Deirdre M. Boucherie, Hannah Creeney, Ruben W. A. van Drie, Fatemeh Farham, Silvia Favaretto, Cédric Gollion, Lou Grangeon, Hannah Lyons, Karol Marschollek, Dilara Onan, Umberto Pensato, Emily Stanyer, Marta Waliszewska-Prosół, Wietse Wiels, Hui Zhou Chen…
    Citation: The Journal of Headache and Pain 2023 24:76
    Content type: Review Published on:

  34. Real-world data are accumulating on the effectiveness, tolerability and safety of anti-calcitonin gene-related peptide pathway monoclonal antibodies for the preventive treatment of migraine. We performed a sys...

    Authors: Nicolas Vandenbussche, Karolina Pisarek and Koen Paemeleire
    Citation: The Journal of Headache and Pain 2023 24:75
    Content type: Review Published on:

  35. Authors: Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:74
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2023 24:60

  37. Advanced neuroimaging techniques have extensively contributed to elucidate the complex mechanisms underpinning the pathophysiology of migraine, a neurovascular disorder characterized by episodes of headache as...

    Authors: Antonio Russo, Marcello Silvestro, Alessandro Tessitore, Ilaria Orologio, Alessandro Pasquale De Rosa, Rosa De Micco, Gioacchino Tedeschi, Fabrizio Esposito and Mario Cirillo
    Citation: The Journal of Headache and Pain 2023 24:71
    Content type: Review Published on:

  38. Repeat mild traumatic brain injuries (RmTBI) result in substantial burden to the public health system given their association with chronic post-injury pathologies, such as chronic pain and post-traumatic heada...

    Authors: Jennaya Christensen, Naomi MacPherson, Crystal Li, Glenn R. Yamakawa and Richelle Mychasiuk
    Citation: The Journal of Headache and Pain 2023 24:72
    Content type: Research Published on:

  39. Erenumab has demonstrated effectiveness for prevention of migraine attacks, but the treatment is costly, and a considerable proportion of patients do not respond to it. The Registry for Migraine study (REFORM)...

    Authors: William Kristian Karlsson, Håkan Ashina, Christopher Kjær Cullum, Rune Häckert Christensen, Haidar Muhsen Al-Khazali, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:70
    Content type: Research Published on:

  40. Migraine is a debilitating disorder, and while the introduction of monoclonal antibodies (mAbs) has led to efficacious and tolerable responses, a substantial number of patients are so-called “non-responders”. ...

    Authors: Linda Al-Hassany, Nazia Karsan, Christian Lampl, Peter J. Goadsby and Antoinette MaassenVanDenBrink
    Citation: The Journal of Headache and Pain 2023 24:69
    Content type: Correspondence Published on:

  41. The main objective of this clinical practice guideline is to provide a series of recommendations for healthcare and exercise professionals, such as neurologists, physical therapists, and exercise physiologists...

    Authors: Roy La Touche, José Fierro-Marrero, Irene Sánchez-Ruíz, Borja Rodríguez de Rivera-Romero, Carlos Donato Cabrera-López, Sergio Lerma-Lara, Néstor Requejo-Salinas, Francisco de Asís-Fernández, Ignacio Elizagaray-García, Josué Fernández-Carnero, Luís Matesanz-García, Joaquín Pardo-Montero, Alba Paris-Alemany and Álvaro Reina-Varona
    Citation: The Journal of Headache and Pain 2023 24:68
    Content type: Research Published on:

  42. Migraine is a disabling neurological disorder whose diagnosis is based on clinical criteria. A shortcoming of these criteria is that they do not fully capture the underlying neurobiological factors and sex-spe...

    Authors: F. C. van Welie, L. A. Kreft, J. M. A. Huisman and G. M. Terwindt
    Citation: The Journal of Headache and Pain 2023 24:64
    Content type: Review Published on:

  43. Authors: Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Mikael H. Sodergren, Sara Facchetti, Barbara Pacchetti, Michela Palmisani, Valentina Franco and Cristina Tassorelli
    Citation: The Journal of Headache and Pain 2023 24:67
    Content type: Correction Published on:

    The original article was published in The Journal of Headache and Pain 2023 24:48

  44. Chronic migraine (CM) is a common neurological disorder with complex pathogenesis. Evidence suggests that pituitary adenylate cyclase-activating peptide (PACAP) induces migraine-like attacks and may be potenti...

    Authors: Lily Zhang, Yanjie Zhou, Liu Yang, Yue Wang and Zheman Xiao
    Citation: The Journal of Headache and Pain 2023 24:66
    Content type: Research Published on:

  45. Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller ...

    Authors: Zhengming Shan, Yajuan Wang, Tao Qiu, Yanjie Zhou, Yu Zhang, Luyu Hu, Lili Zhang, Jingjing Liang, Man Ding, Shanghua Fan and Zheman Xiao
    Citation: The Journal of Headache and Pain 2023 24:65
    Content type: Research Published on:

  46. Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age res...

    Authors: Albert Muñoz-Vendrell, Sergio Campoy, Edoardo Caronna, Alicia Alpuente, Marta Torres-Ferrus, Candela Nieves Castellanos, Marina Olivier, Jaume Campdelacreu, Joan Prat, Javier Camiña Muñiz, Francisco José Molina Martínez, Ane Mínguez-Olaondo, Marta Ruibal Salgado, Sonia Santos Lasaosa, María Pilar Navarro Pérez, Noemí Morollón…
    Citation: The Journal of Headache and Pain 2023 24:63
    Content type: Research Published on:

  47. Cortical spreading depression (CSD), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura and a h...

    Authors: Chiho Kudo, Andrea M. Harriott, Michael A. Moskowitz, Christian Waeber and Cenk Ayata
    Citation: The Journal of Headache and Pain 2023 24:62
    Content type: Research Published on:

  48. Migraine is a highly disabling health burden with multiple symptoms; however, it remains undertreated because of an inadequate understanding of its neural mechanisms. Neuropeptide Y (NPY) has been demonstrated...

    Authors: Chunxiao Yang, Zihua Gong, Xiaochen Zhang, Shuai Miao, Bozhi Li, Wei Xie, Tao Wang, Xun Han, Liang Wang, Zhao Dong and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:61
    Content type: Research Published on:

  49. Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate...

    Authors: Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin and Messoud Ashina
    Citation: The Journal of Headache and Pain 2023 24:60
    Content type: Research Published on:

    The Correction to this article has been published in The Journal of Headache and Pain 2023 24:74

  50. Neuroimaging studies have made an important contribution to our understanding of headache pathophysiology. This systematic review aims to provide a comprehensive overview and critical appraisal of mechanisms o...

    Authors: R. Messina, R. H. Christensen, I. Cetta, M. Ashina and M. Filippi
    Citation: The Journal of Headache and Pain 2023 24:58
    Content type: Review Published on:
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