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  1. Neuropathic pain (NP) is a sustained and nonreversible condition characterized by long-term devastating physical and psychological damage. Therefore, it is urgent to identify an effective treatment for NP. Unf...

    Authors: Binbin Lin, Yuting Wang, Piao Zhang, Yanyan Yuan, Ying Zhang and Gang Chen

    Citation: The Journal of Headache and Pain 2020 21:103

    Content type: Review article

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  2. Most patients treated with erenumab in clinical practice have chronic migraine (CM). We assessed the rate and possible predictors of conversion from CM to episodic migraine (EM) in a real-life study.

    Authors: Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Valeria Caponnetto, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco

    Citation: The Journal of Headache and Pain 2020 21:102

    Content type: Short report

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  3. Although migraine is one of the most common primary headaches, its therapy is still limited in many cases. The use of animal models is crucial in the development of novel therapeutic strategies, but unfortunat...

    Authors: Klaudia Flóra Laborc, Eleonóra Spekker, Zsuzsanna Bohár, Mónika Szűcs, Gábor Nagy-Grócz, Annamária Fejes-Szabó, László Vécsei and Árpád Párdutz

    Citation: The Journal of Headache and Pain 2020 21:101

    Content type: Methodology

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  4. Psychological distress is highly prevalent among migraineurs during public health emergencies. The coronavirus disease 2019 (nCOV-2019) has created mass panic in China due to its highly contagious by contact a...

    Authors: Mengmeng Ma, Jinghuan Fang, Changling Li, Jiajia Bao, Yang Zhang, Ning Chen, Jian Guo and Li He

    Citation: The Journal of Headache and Pain 2020 21:100

    Content type: Research article

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  5. Migraine is a common and incapacitating condition, with severe impact on the quality of life (QoL) of the afflicted and their families, and negative economic consequences through decreased workforce participat...

    Authors: Amanda Hansson-Hedblom, Isabelle Axelsson, Lena Jacobson, Joakim Tedroff and Fredrik Borgström

    Citation: The Journal of Headache and Pain 2020 21:99

    Content type: Research article

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  6. Previous studies found an association between migraine and dementia, which are two leading causes of disability. However, these studies did not differentiate between migraine types and did not investigate all ...

    Authors: Sabrina Islamoska, Åse Marie Hansen, Hui-Xin Wang, Anne Helene Garde, Per Kragh Andersen, Ellen Garde, Jakob Møller Hansen, Gunhild Waldemar and Kirsten Nabe-Nielsen

    Citation: The Journal of Headache and Pain 2020 21:98

    Content type: Research article

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  7. Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between o...

    Authors: Espen Saxhaug Kristoffersen, Sigrid Børte, Knut Hagen, John-Anker Zwart and Bendik Slagsvold Winsvold

    Citation: The Journal of Headache and Pain 2020 21:97

    Content type: Research article

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  8. Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of t...

    Authors: Nuria García-Magro, Pilar Negredo, Yasmina B. Martin, Ángel Nuñez and Carlos Avendaño

    Citation: The Journal of Headache and Pain 2020 21:96

    Content type: Research article

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  9. We performed a post hoc, subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled study of erenumab for prevention of episodic migraine (STRIVE) to determine the efficacy and safety of eren...

    Authors: Jelena M. Pavlovic, Koen Paemeleire, Hartmut Göbel, Jo Bonner, Alan Rapoport, Risa Kagan, Feng Zhang, Hernan Picard and Daniel D. Mikol

    Citation: The Journal of Headache and Pain 2020 21:95

    Content type: Research article

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  10. Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if pati...

    Authors: Javier Trigo, David García-Azorín, Álvaro Planchuelo-Gómez, Enrique Martínez-Pías, Blanca Talavera, Isabel Hernández-Pérez, Gonzalo Valle-Peñacoba, Paula Simón-Campo, Mercedes de Lera, Alba Chavarría-Miranda, Cristina López-Sanz, María Gutiérrez-Sánchez, Elena Martínez-Velasco, María Pedraza, Álvaro Sierra, Beatriz Gómez-Vicente…

    Citation: The Journal of Headache and Pain 2020 21:94

    Content type: Research article

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  11. Post-traumatic headache (PTH) is one of the most frequent symptoms following mild traumatic brain injury (mTBI). Neuroimaging studies implicate hypothalamic function connectivity (FC) disruption as an importan...

    Authors: Liyan Lu, Fengfang Li, Peng Wang, Huiyou Chen, Yu-Chen Chen and Xindao Yin

    Citation: The Journal of Headache and Pain 2020 21:93

    Content type: Research article

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  12. We investigated intracerebral fiber bundles using a tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) data to verify microstructural integrity in patients with episodic (MO) and ...

    Authors: Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Barbara Petolicchio, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Francesca Caramia, Vittorio Di Piero and Francesco Pierelli

    Citation: The Journal of Headache and Pain 2020 21:92

    Content type: Research article

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  13. Trigeminal neuralgia (TN) is an orofacial condition defined by reoccurring, spontaneous, short-lived but excruciating stabbing pain. Pharmacological interventions constitute the first-line treatment for TN, wi...

    Authors: Rachel O. Coats, Kirsty L. Crossley, Naomi Conlin, Jianhua Wu, Joanna M. Zakrzewska, Sue H. Pavitt, Nicholas Phillips and Mark Mon-Williams

    Citation: The Journal of Headache and Pain 2020 21:91

    Content type: Research article

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  14. According to the International Classification of Headache Disorders 3, post-traumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary headache reported to have developed within 7 days ...

    Authors: Silvia Benemei, Alejandro Labastida-Ramírez, Ekaterina Abramova, Nicoletta Brunelli, Edoardo Caronna, Paola Diana, Roman Gapeshin, Maxi Dana Hofacker, Ilaria Maestrini, Enrique Martínez Pías, Petr Mikulenka, Olga Tikhonova, Paolo Martelletti and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2020 21:90

    Content type: Review article

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  15. Voxel-based morphometry (VBM) is a popular non-invasive magnetic resonance imaging technique to investigate brain gray matter (GM) differences between groups. Recently, two VBM studies in migraine have been pu...

    Authors: Hong Zhou Wang, Wan Hua Wang, Hai Cun Shi and Cong Hu Yuan

    Citation: The Journal of Headache and Pain 2020 21:89

    Content type: Commentary

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  16. There is a need to establish which are the more relevant headache-related outcomes that have an impact on our patient’s lives to accurately evaluate treatment response in daily clinical practice.

    Authors: Marta Torres-Ferrus, Victor José Gallardo, Alicia Alpuente and Patricia Pozo-Rosich

    Citation: The Journal of Headache and Pain 2020 21:88

    Content type: Research article

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  17. Stimulation of trigeminovascular pathway is widely used to establish the headache animal model. Headache is a common neurological disorder, in which symptomatic attacks are mediated by calcitonin-gene-related ...

    Authors: Ya-Tin Lin, Zachary Yu, Sze-Chi Tsai, Po-Hung Hsu and Jin-Chung Chen

    Citation: The Journal of Headache and Pain 2020 21:87

    Content type: Short report

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    The Correction to this article has been published in The Journal of Headache and Pain 2020 21:140

  18. Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarizati...

    Authors: Andrea Negro, Jessica L. Seidel, Thijs Houben, Esther S. Yu, Ike Rosen, Andrea J. Arreguin, Nilufer Yalcin, Lea Shorser-Gentile, Lea Pearlman, Homa Sadhegian, Ramalingam Vetrivelan, Nancy L. Chamberlin, Cenk Ayata, Paolo Martelletti, Michael A. Moskowitz and Katharina Eikermann-Haerter

    Citation: The Journal of Headache and Pain 2020 21:86

    Content type: Research article

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  19. Migraine is a frequent headache disorder with high disease burden. The aims of this study were to determine the administrative prevalence and incidence of migraine in Germany; and to elucidate disease characte...

    Authors: Tatjana Roessler, Juergen Zschocke, Anne Roehrig, Michael Friedrichs, Heiko Friedel and Zaza Katsarava

    Citation: The Journal of Headache and Pain 2020 21:85

    Content type: Research article

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  20. Calcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding ef...

    Authors: Armin Scheffler, Olga Messel, Sebastian Wurthmann, Michael Nsaka, Christoph Kleinschnitz, Martin Glas, Steffen Naegel and Dagny Holle

    Citation: The Journal of Headache and Pain 2020 21:84

    Content type: Research article

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  21. Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA recepto...

    Authors: Diego Currò, Pierluigi Navarra, Irene Samengo and Maria Martire

    Citation: The Journal of Headache and Pain 2020 21:83

    Content type: Research article

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  22. Trigeminal neuralgia (TN) is a severe, disabling form of painful cranial neuropathy. Even though TN has a typical clinical picture, diagnosis it is often missed or delayed in clinical practice. In order to inv...

    Authors: F. Antonaci, S. Arceri, M. Rakusa, D. D. Mitsikostas, I. Milanov, V. Todorov, M. Cotta Ramusino and A. Costa

    Citation: The Journal of Headache and Pain 2020 21:82

    Content type: Research article

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  23. Many studies have described the features of menstrually-related migraines (MRM) in the natural cycle and the efficacy of prevention. MRM in combined hormonal contraceptive (CHC) users has scarcely been researc...

    Authors: Gabriele S. Merki-Feld, Nina Caveng, Gina Speiermann and E. Anne MacGregor

    Citation: The Journal of Headache and Pain 2020 21:81

    Content type: Research article

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  24. Primary headache disorders have being increasingly reported in younger populations. They can have significant effects on their quality of life and academic achievement and may cause significant distress to the...

    Authors: Jasem Y. Al-Hashel, R. Alroughani, S. Shuaibi, A. AlAshqar, F. AlHamdan, H. AlThufairi, S. Owayed and Samar F. Ahmed

    Citation: The Journal of Headache and Pain 2020 21:80

    Content type: Research article

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    The Correction to this article has been published in The Journal of Headache and Pain 2021 22:7

  25. Migraine clinical profile may change with age, making it necessary to verify that migraine treatments are equally safe and effective in older patients. These analyses evaluated the effects of patient age on th...

    Authors: Virginia L. Stauffer, Ira Turner, Phebe Kemmer, William Kielbasa, Kathleen Day, Martha Port, Tonya Quinlan and Angelo Camporeale

    Citation: The Journal of Headache and Pain 2020 21:79

    Content type: Research article

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  26. Chronic pain surrounding the temporomandibular joints and masticatory muscles is often the primary chief complaint of patients with temporomandibular disorders (TMD) seeking treatment. Yet, the neuro-pathophys...

    Authors: Yuanyuan Yin, Shushu He, Jingchen Xu, Wanfang You, Qian Li, Jingyi Long, Lekai Luo, Graham J. Kemp, John A. Sweeney, Fei Li, Song Chen and Qiyong Gong

    Citation: The Journal of Headache and Pain 2020 21:78

    Content type: Review article

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  28. Despite advances in the management of headache disorders, some patients with migraine do not experience adequate pain relief with acute and preventive treatments. It is the aim of the present document to provi...

    Authors: Simona Sacco, Mark Braschinsky, Anne Ducros, Christian Lampl, Patrick Little, Antoinette Maassen van den Brink, Patricia Pozo-Rosich, Uwe Reuter, Elena Ruiz de la Torre, Margarita Sanchez Del Rio, Alexandra J. Sinclair, Zaza Katsarava and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2020 21:76

    Content type: Consensus article

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  29. This study evaluates the accuracy of an automated classification tool of single attacks of the two major primary headache disorders migraine and tension-type headache used in an electronic headache diary.

    Authors: Aaron Roesch, Markus A Dahlem, Lars Neeb and Tobias Kurth

    Citation: The Journal of Headache and Pain 2020 21:75

    Content type: Research article

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  30. Headache is one of the most prevalent diseases. The Global Burden of Disease Study ranks it as the seventh most common disease overall and the second largest neurological cause of disability in the world. The ...

    Authors: Patricia Pozo-Rosich, Almudena Layos-Romero, Jimmy Martin-Delgado, Julio Pascual, Cristina Bailón, Ana Tentor, Alejandro Santiago, Emilio Ignacio, Antonio Torrés and José Joaquín Mira

    Citation: The Journal of Headache and Pain 2020 21:74

    Content type: Research article

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  31. While the Global Burden of Disease (GBD) study reports headache disorders as the second-highest cause of disability worldwide, the headache data in GBD come very largely from adults. This national study in Lit...

    Authors: Diana Genc, Nerija Vaičienė-Magistris, Apolinaras Zaborskis, Tayyar Şaşmaz, Aylin Yeniocak Tunç, Derya Uluduz and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2020 21:73

    Content type: Research article

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  32. Vestibular migraine has recently been recognized as a novel subtype of migraine. However, the mechanism that relate vestibular symptoms to migraine had not been well elucidated. Thus, the present study investi...

    Authors: Yun Zhang, Yixin Zhang, Ke Tian, Yunfeng Wang, Xiaoping Fan, Qi Pan, Guangcheng Qin, Dunke Zhang, Lixue Chen and Jiying Zhou

    Citation: The Journal of Headache and Pain 2020 21:72

    Content type: Research article

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  33. Migraine is a leading cause of disability worldwide, but it is still underdiagnosed and undertreated. Research on the pathophysiology of this neurological disease led to the discovery that calcitonin gene-rela...

    Authors: David B. Clemow, Kirk W. Johnson, Helen M. Hochstetler, Michael H. Ossipov, Ann M. Hake and Andrew M. Blumenfeld

    Citation: The Journal of Headache and Pain 2020 21:71

    Content type: Review article

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  34. There are no previous controlled studies of sentinel headache in ischemic stroke. The purpose of the present study was to evaluate the presence of such headache, its characteristics and possible risk factors a...

    Authors: Elena R. Lebedeva, Anton V. Ushenin, Natalia M. Gurary, Denis V. Gilev and Jes Olesen

    Citation: The Journal of Headache and Pain 2020 21:70

    Content type: Research article

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  35. erenumab was safe and effective in clinical trials for the prevention of migraine. However, real-life data are still lacking. Here we report the clinical experience from an Italian real-world setting using ere...

    Authors: Antonio Russo, Marcello Silvestro, Fabrizio Scotto di Clemente, Francesca Trojsi, Alvino Bisecco, Simona Bonavita, Alessandro Tessitore and Gioacchino Tedeschi

    Citation: The Journal of Headache and Pain 2020 21:69

    Content type: Research article

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  36. Productivity and monetary loss due to migraine in the workplace may be substantial. This study aimed to determine the impact of migraine on productivity and monetary lost among employees in the banking sectors...

    Authors: Li Ping Wong, Haridah Alias, Nirmala Bhoo-Pathy, Ivy Chung, Yew Ching Chong, Sonesh Kalra and Zia U Bahkt Sultan Shah

    Citation: The Journal of Headache and Pain 2020 21:68

    Content type: Research article

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    The Correction to this article has been published in The Journal of Headache and Pain 2020 21:104

  37. Several previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investig...

    Authors: Knut Hagen, Lars Jacob Stovner and John-Anker Zwart

    Citation: The Journal of Headache and Pain 2020 21:67

    Content type: Research article

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  38. Migraine has been recognized as one of common diseases in the world whose current treatment options are not ideal. Lasmiditan, an oral 5-hydroxytryptamine (HT)1F receptor agonist, appears more promising for the a...

    Authors: Min Hou, Haiyan Xing, Chen Li, Xianfeng Wang, Dongmei Deng, Juan Li, Pan Zhang and Jianhong Chen

    Citation: The Journal of Headache and Pain 2020 21:66

    Content type: Research article

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  39. The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and ...

    Authors: J. C. A. Edvinsson, A. Viganò, A. Alekseeva, E. Alieva, R. Arruda, C. De Luca, N. D’Ettore, I. Frattale, M. Kurnukhina, N. Macerola, E. Malenkova, M. Maiorova, A. Novikova, P. Řehulka, V. Rapaccini, O. Roshchina…

    Citation: The Journal of Headache and Pain 2020 21:65

    Content type: Review article

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  40. Migraine is a common brain disorder with a large genetic component. Of the two main migraine types, migraine with aura and migraine without aura, the genetic underpinning in the former is least understood. Giv...

    Authors: Irene de Boer, Gisela M. Terwindt and Arn M. J. M. van den Maagdenberg

    Citation: The Journal of Headache and Pain 2020 21:64

    Content type: Review article

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  42. Calcitonin gene-related peptide (CGRP) has recently been implicated in the pathogenesis of post-traumatic headache (PTH), which raises the prospect for therapeutic use of monoclonal antibodies targeting CGRP o...

    Authors: Håkan Ashina, Afrim Iljazi, Haidar Muhsen Al-Khazali, Anna Kristina Eigenbrodt, Eigil Lindekilde Larsen, Amalie Middelboe Andersen, Kevin John Hansen, Karoline Bendix Bräuner, Thomas Mørch-Jessen, Basit Chaudhry, Sonja Antic, Casper Emil Christensen, Messoud Ashina, Faisal Mohammad Amin and Henrik Winther Schytz

    Citation: The Journal of Headache and Pain 2020 21:62

    Content type: Research article

    Published on:

  43. Clinical trials have shown the safety and clinical superiority of erenumab compared to placebo in chronic migraine (CM). The aim of this analysis is to evaluate the effectiveness and tolerability of erenumab i...

    Authors: Giorgio Lambru, Bethany Hill, Madeleine Murphy, Ivona Tylova and Anna P. Andreou

    Citation: The Journal of Headache and Pain 2020 21:61

    Content type: Research article

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  45. There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribut...

    Authors: Tiffani J. Mungoven, Noemi Meylakh, Kasia K. Marciszewski, Vaughan G. Macefield, Paul M. Macey and Luke A. Henderson

    Citation: The Journal of Headache and Pain 2020 21:59

    Content type: Research article

    Published on:

  46. Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission.

    Authors: Byung-Su Kim, Pil-Wook Chung, Byung-Kun Kim, Mi Ji Lee, Jeong Wook Park, Min Kyung Chu, Jin-Young Ahn, Dae Woong Bae, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh, Daeyoung Kim, Jae-Moon Kim, Soo-Kyoung Kim, Yun-Ju Choi, Jae Myun Chung…

    Citation: The Journal of Headache and Pain 2020 21:58

    Content type: Research article

    Published on:

  47. Neck pain in migraine patients is very prevalent between and during migraine attacks, but the underlying mechanism behind neck pain in migraine is unknown. The neck muscle rectus capitis posterior minor muscle...

    Authors: Jeppe Hvedstrup, Faisal Mohammad Amin, Anders Hougaard, Håkan Ashina, Casper Emil Christensen, Henrik Bo Wiberg Larsson, Messoud Ashina and Henrik Winther Schytz

    Citation: The Journal of Headache and Pain 2020 21:57

    Content type: Research article

    Published on:

  48. Vestibular symptoms and balance changes are common in patients with migraine, especially in the ones with aura and chronic migraine. However, it is not known if the balance changes are determined by the presen...

    Authors: Letícia Zorzin, Gabriela F. Carvalho, Jens Kreitewolf, Roberto Teggi, Carina F. Pinheiro, Jéssica R. Moreira, Fabíola Dach and Débora Bevilaqua-Grossi

    Citation: The Journal of Headache and Pain 2020 21:56

    Content type: Research article

    Published on:

  49. Headache is a common complication of traumatic brain injury. The International Headache Society defines post-traumatic headache as a secondary headache attributed to trauma or injury to the head that develops ...

    Authors: Alejandro Labastida-Ramírez, Silvia Benemei, Maria Albanese, Antonina D’Amico, Giovanni Grillo, Oxana Grosu, Devrimsel Harika Ertem, Jasper Mecklenburg, Elena Petrovna Fedorova, Pavel Řehulka, Francesca Schiano di Cola, Javier Trigo Lopez, Nina Vashchenko, Antoinette MaassenVanDenBrink and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2020 21:55

    Content type: Review article

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  50. Pregabalin is approved for the treatment of neuropathic pain, fibromyalgia, and seizure disorders, although the pivotal trials were mostly carried out in Europe or North America. The prescribing patterns among...

    Authors: Yen-Feng Wang, Yung-Tai Chen, Ching-Wen Tsai, Yu-Chun Yen, Yi-Chun Chen, Ben-Chang Shia and Shuu-Jiun Wang

    Citation: The Journal of Headache and Pain 2020 21:54

    Content type: Research article

    Published on:

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