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Surgical treatment of trigeminal neuralgia: results of percutaneous treatment versus microsurgical decompression

A patient with trigeminal neuralgia may need different forms of treatment during his or her lifetime. Physicians should be aware of the different available surgical treatments, and know their effectiveness, s...

Authors: Mario Meglio, Beatrice Cioni, Gianpiero Tamburrini, Luigi Pentimalli and Yi Ma

The cost of the migraine patient in Italy

To estimate the cost of the migraine patient in Italy, we undertook an observational, multicenter study. The study was carried out by 902 Italian general practitioners (GPs). GPs asked patients over 14 years ...

Authors: Maurizio Roncolato, Fabio Arpinelli, Laura Fabbri, Francesco Manetta, Giovanni Visonà, Ovidio Brignoli and Gerardo Medea

Dopamine D1-D5 receptor protein immunohistochemistry in dog pial arteries

The localization of dopamine D1-D5 receptor protein was investigated in different sized dog pial arteries. This was done to further understand the pathophysiology of cerebrovascular dopaminergic system in mig...

Authors: Francesco Amenta, Roberto Avola, Elena Bronzetti, Laura Felici, Giovanni Germanà, Fiorenzo Mignini, Alberto Ricci and Maurizio Sabbatini

Headache and neck pain: Gabapentin as a possible treatment

Pain is a common situation and it is one of the most frequent presenting symptoms of different pathologies. Treating pain could be a precise request to the doctor, from the patient and his caregiver. Manageme...

Authors: Rita Moretti, Rodolfo M. Antonello, Paola Torre and Giuseppe Cazzato

Nitric oxide in primary headaches

Nitric oxide (NO) has been proposed to be a key molecule in migraine. Experimental evidence suggests its intervention in vasodilatation and activation of the trigeminovascular system as well as its involvemen...

Authors: Virgilio Gallai and Paola Sarchielli

Co-morbidity of migraine and epilepsy: a review of clinical features

Migraine and epilepsy are common neurological conditions that often co-exist. There are some common symptoms and in some patients there may be a diagnostic problem. The purpose of this study was to review the...

Authors: Danny Flanagan and Karabi Ghose

Cerebral polyopia in migraine: a clinical case

We describe an 8-year-old, with a 1-year history of migraine without aura who experienced an episode of unusual visual aura, characterised by a fourfold view of her mother's image. These images were clearly v...

Authors: Vincenzo Raieli, Gian Luca Eliseo, Girolama La Franca, Michela La Vecchia, Domenico Puma and Mario Eliseo

Mothers and pain: the effect of a mother's pain experience on the child

How does the preceding experience of pain by the mother affect the child's response to the painful event? This work intends to be a preliminary answer to this problem. A questionnaire with 10 items was admini...

Authors: Davide Moscato, Angela Regine, Francesca Ribaudo and Anna Vignali

Desialylated transferrin in plasma of patients with migraine without aura

Patients with migraine, without aura (MO), either during or between attacks, present elevated histamine levels in platelet-poor plasma but normal whole blood histamine levels, compared with controls. This fin...

Authors: Jean-Marie Launay, François Tabuteau and André Pradalier

Cortical excitability in migraine

Cortical hyperexcitability in migraine has been suggested to play a pivotal role in triggering migraine attacks, possibly via generation of spreading depression. Low levels of plasma, intracellular and brain ...

Authors: Judit Áfra

Chronic daily headache: biochemical and neurotransmitter abnormalities

Although chronic daily headache (CDH) represents one of the most relevant complaints of patients in headache centers, the mechanisms underlying the chronicization of head pain are poorly understood. Experimen...

Authors: Virgilio Gallai, Paola Sarchielli, Sergio Genco, Andrea Alberti and Giovanni D'Andrea

Genetic factors in migraine and chronic tension-type headache

Pathophysiological studies have dominated migraine research for several years. However, these studies are difficult to interpret because it is difficult to decide whether the observed phenomena are primary or...

Authors: Michael Bjørn Russell

Molecular genetics and migraine

Migraine carries a significant hereditary determination. Familial hemiplegic migraine (FHM) has been recently linked to mutations in the CACNA1A gene on chromosome 19. CACNA1A codes for a subunit of a neural ...

Authors: Pasquale Montagna

CACNA1A gene mutations in familial hemiplegic migraine

Familial hemiplegic migraine (FHM) is an autosomal dominant subtpye of migraine with aura. A few years ago, the gene linked to FHM was identified. CACNA1A encodes a voltage-activated, pore-forming α1A subunit...

Authors: Arn M.J.M. van den Maagdenberg, Joerg Striessnig, Michel D. Ferrari and Rune R. Frants

HLA and disease association

The major histocompatibility complex (MHC) is a genetic system of over 70 known genes on the short arm of chromosome 6 and spans about 4 million base pairs of DNA. The high resolution typing of class I and cl...

Authors: Simonetta Trabace

Psychopatholigical factors in chronic headache: an overview

Authors: F. Puca

Clinical neurophysiology of chronic daily headache

The pathophysiology of chronic daily headache is unclear. Clinical research aiming to elucidate causative mechanisms is often confounded by the variability of factors involved. Furthermore, there is a recent ...

Authors: Marina de Tommaso, Vittorio Sciruicchio and Francomichele Puca

Chronic daily headache: a Rorschach study

The aim of this study was to describe the distinctive personality traits and their interest to the development of a chronic form of headache, by means of the Rorschach test, a projective approach, in an autom...

Authors: Pierluigi Scapicchio, Dario De Fidio, Francomichele Puca, Vittorio Sciruicchio, Maria Nicolodi, Stefania Canova, Domenico D'Amico, Giuseppe Libro, Giorgio Zanchin, Anna Pia Verri, Giorgio Sandrini, Andrea Alberti, Susanna Russo, Piero Barbanti and Teresa Catarci

Chronic daily headache: personality study by means of computerized MMPI-2

Unresolved questions in headache research are the roles of drug abuse and psychopathology in headache disorder, especially in chronic daily headache. We investigated the utility of the revised version of the ...

Authors: Dario De Fidio, Vittorio Sciruicchio, Beatrice Pastore, Maria Pia Prudenzano, Elisa Di Pietro, Alfonso Tramontano, Angelo Lorizio, Franco Granella, Gennaro Bussone, Licia Grazzi and Paola Sarchielli

Stress and chronic headache

The aims of this study were to assess how stress affects chronic headaches, and in particular to determine whether events play a role in the transformation of an episodic headache into a chronic form. A popul...

Authors: Domenico D'Amico, Giuseppe Libro, Maria Pia Prudenzano, Cesare Peccarisi, Mario Guazzelli, Giuliano Relja, Francomichele Puca, Sergio Genco, Ferdinando Maggioni, Giuseppe Nappi, Anna Pia Verri, Rosanno Cerbo and Gennaro Bussone

Memory functions in patients with chronic daily headache

Memory loss is a common complaint in headache sufferers. 71 patients, 50 women and 21 men, affected by chronic daily headache with different diagnoses at onset and at study entry underwent a test battery in o...

Authors: Mariantonietta Savarese, Maria Pia Prudenzano, Teresa Francavilla, Mauro Palumbo, Maria Nicolodi, Stefania Canova, Giorgio Zanchin, Franco Granella, Andrea Alberti, Susanna Russo, Rosanna Cerbo and Antonio Carolei

Clinical and descriptive analysis of chronic daily headaches

With an ad hoc, previously validated clinical record, we analysed the headache characteristics in 245 patients (F, 78.4%, M, 21,6%; mean age, 43.1±12.9 years) affected by chronic daily headache (CDH) attendin...

Authors: Franco Granella, Giorgio Sandrini, Maria Pia Prudenzano, Teresa Francavilla, Giuseppe Pietrarossa, Vittorio Sciruicchio, Maria Nicolodi, Stefania Canova, Gennaro Bussone, Domenico D'Amico, Giuseppe Libro, Susanna Usai, Giorgio Zanchin, Giuseppe Nappi, Virgilio Gallai, Paola Sarchielli…

Chronic daily headache: old problems, new vistas

In 1988 the problems concerning chronic daily headache (CDH) were neglected by the classification of the International Headache Society (IHS). More than ten years later, this issue is still debated, also in l...

Authors: Guiseppe Nappi, Alfredo Costa, Cherubino Di Lorenzo, Alberto Proietti Cecchini, Ennio Pucci and Giorgio Sandrini

Primary headache and comorbidity with mood and anxiety disorders: an example of the psycho-neuro-biological loop

Although an association between primary headache and psychiatric disorders, has been recognised for over 100 years, this association has been investigated systematically only recently. The nature of this asso...

Authors: Laura Palagini, Elisabetta L. Balsamo, Patrizia Panicucci and Mario Guazzelli

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The hypnic headache syndrome: the first description of an Italian case

Authors: Giorgio Zanchin, Carlo Lisotto and Ferdinando Maggioni

Transient global amnesia occurring as migraine aura

We describe a case of transient global amnesia (TGA) occurring as migraine aura. TGA prevalence is higher among migraineurs and has been ascribed to spreading depression in the hippocampus. Our patient, a 38-...

Authors: Pasquale Montagna, Angelina Cerullo and Pietero Cortelli

Pain reactivity in children with autistic disorder

Abnormal pain reactivity is often reported by the parents of children with autistic disorder (AD). This is an interesting feature because it could be related to some neurochemical findings frequently reported...

Authors: Roberto Militerni, Carmela Bravaccio, Carmelinda Falco, Stefano Puglisi-Allegra, Tiziana Pascucci and Cinzia Fico

An Italian pilot study on the use of the migraine disability assessment questionnaire

The migraine disability assessment questionnaire (MIDAS) is a recently developed, validated questionnaire for assessing the impact of migraine on individual patients. We carried out a pilot study to assess th...

Authors: Domenico D'Amico, Alessandra Ferraris, Licia Grazzi, Susanna Usai, Massimo Leone and Gennaro Bussone

Trigeminal evoked potentials in cluster headache

We sought out alterations of early trigeminal evoked potenials (TEPs) in patients suffering from episodic cluster headache, in order to evaluate a possible direct involvement of the trigeminal nerve. The stud...

Authors: Massimo Leandri, Massimo Luzzani and Alberto Gottlieb

Vestibular disorders in migrainous children and adolescents

Recurrent vertigo is a special form of migraine in childhood. It is a periodic syndrome of childhood which was previously called migraine equivalent. Thirty young patients (less than 18 years of age) with mig...

Authors: Ágnes Szirmai and Viktor Farkas

Sumatriptan (50 and 100 mg) in repeated migraine attacks: a patient preference study

Oral sumatriptan in 100-mg tablets is an effective and well tolerated treatment for the acute migraine attack. Since the launch of that dose, further studies have suggested good efficacy also for lower doses....

Authors: Georgio Zanchin, Maurizio Roncolato and Laura Fabbri

Conjunctival congestion in SUNCT syndrome

The purpose of this observational-retrospective study was to assess which type of conjunctival injection and related phenomena are present during SUNCT attacks. We studied the videorecords of 23 SUNCT attacks...

Authors: Juan A. Pareja, Julia Pareja, Julio Yangüela and Pablo Gili

Psychological and social stressors and psychiatric comorbidity in patients with migraine without aura from headache centers in Italy: a comparison with tension-type headache patients

A multicenter study was carried out to investigate the prevalence of psychosocial stressors and psychiatric comorbidity in patients suffering from migraine without aura (MWO) according to the International He...

Authors: Francomichele Puca

A population-based follow-up study of headache from age 7 to 22 years

To study changes in headache prevalence during childhood, adolescence and early adulthood, we performed a prospective long-term follow-up study on an unselected child population. Seven-year-old children, resi...

Authors: Minna Aromaa, Matti Sillanpää and Hillevi Aro

Molecular chronobiology

Recent years have seen exciting advances in the understanding of the mechanisms that underlie circadian rhythms in a variety of organisms, including mammals. Several key genes have been identified, whose prod...

Authors: Charalambos Panayiotis Kyriacou

Guest editorial

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The debut of The Journal of Headache and Pain

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