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  1. The introduction of monoclonal antibodies (mAbs) against calcitonin-gene related peptide (CGRP) or CGRP receptors in the treatment of migraine raised concerns on the possible risks associated to the long-term ...

    Authors: Giuseppe Tringali, Catello Vollono, Paolo Calabresi and Pierluigi Navarra

    Citation: The Journal of Headache and Pain 2020 21:124

    Content type: Short report

    Published on:

  2. Focus on the frequency of migraine pain may undervalue the total burden of migraine as pain duration and severity may present unique, additive burden. A composite measure of total pain burden (TPB; frequency, ...

    Authors: Jessica Ailani, J. Scott Andrews, Mallikarjuna Rettiganti and Robert A. Nicholson

    Citation: The Journal of Headache and Pain 2020 21:123

    Content type: Research article

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  3. Migraine can manifest with an episodic or a chronic pattern in a continuum of disease severity. Multiple factors are associated with the progression of the pattern from episodic to chronic. One of the most con...

    Authors: Rosaria Greco, Roberto De Icco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Grazia Sances, Marta Allena and Cristina Tassorelli

    Citation: The Journal of Headache and Pain 2020 21:122

    Content type: Research article

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  4. Headache is the most common COVID-19-related neurological symptom. We aimed to reveal diagnostic clues of headache for COVID-19 infection and to investigate the course of primary headaches during the pandemic.

    Authors: Özge Uygun, Mustafa Ertaş, Esme Ekizoğlu, Hayrunnisa Bolay, Aynur Özge, Elif Kocasoy Orhan, Arif Atahan Çağatay and Betül Baykan

    Citation: The Journal of Headache and Pain 2020 21:121

    Content type: Research article

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  5. PROMISE-2 was a phase 3, randomized, double-blind, placebo-controlled study that evaluated the efficacy and safety of repeat intravenous (IV) doses of the calcitonin gene-related peptide–targeted monoclonal an...

    Authors: Stephen Silberstein, Merle Diamond, Nada A. Hindiyeh, David M. Biondi, Roger Cady, Joe Hirman, Brent Allan, Susan Pederson, Barbara Schaeffler and Jeff Smith

    Citation: The Journal of Headache and Pain 2020 21:120

    Content type: Research article

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  6. Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mecha...

    Authors: Guoliang Chen, Yansong Li, Zhao Dong, Rongfei Wang, Dengfa Zhao, Ignacio Obeso and Shengyuan Yu

    Citation: The Journal of Headache and Pain 2020 21:119

    Content type: Research article

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  7. A global My Migraine Voice survey was conducted in 31 countries among 11,266 adults who suffered from ≥4 monthly migraine days (MMD). The aim of this retrospective observational survey-based study was to analyse ...

    Authors: Marja-Liisa Sumelahti, Markku Sumanen, Merika S. Sumanen, Samuli Tuominen, Johanna Vikkula, Sanna M. Honkala, Stina Rosqvist and Minna A. Korolainen

    Citation: The Journal of Headache and Pain 2020 21:118

    Content type: Research article

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  8. Despite recent publications, practitioners remain unfamiliar with the current terminology related to the placebo and nocebo phenomena observed in clinical trials and practice, nor with the factors that modulat...

    Authors: Dimos D. Mitsikostas, Charlotte Blease, Elisa Carlino, Luana Colloca, Andrew L. Geers, Jeremy Howick, Andrea W. M. Evers, Magne A. Flaten, John M. Kelley, Irving Kirsch, Regine Klinger, Antoinette MaassenVanDenBrink, Daniel E. Moerman, Petros P. Sfikakis, Lene Vase, Tor D. Wager…

    Citation: The Journal of Headache and Pain 2020 21:117

    Content type: Consensus article

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  9. Headache is the dominant factor for quality of life related disability in idiopathic intracranial hypertension (IIH) and typically has migraine-like characteristics. There are currently no evidence-based thera...

    Authors: Andreas Yiangou, James L. Mitchell, Vivek Vijay, Olivia Grech, Edward Bilton, Gareth G. Lavery, Claire Fisher, Julie Edwards, Susan P. Mollan and Alexandra J. Sinclair

    Citation: The Journal of Headache and Pain 2020 21:116

    Content type: Case report

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  10. Since the declaration COVID-19 as a pandemic, healthcare systems around the world have faced a huge challenge in managing patients with chronic diseases. Patients with migraine were specifically vulnerable to ...

    Authors: Jasem Y. Al-Hashel and Ismail Ibrahim Ismail

    Citation: The Journal of Headache and Pain 2020 21:115

    Content type: Research article

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  11. We evaluated the efficacy of fremanezumab, a fully humanized monoclonal antibody that selectively targets calcitonin gene-related peptide, in patients with chronic migraine (CM) with and without medication ove...

    Authors: Stephen D. Silberstein, Joshua M. Cohen, Michael J. Seminerio, Ronghua Yang, Sait Ashina and Zaza Katsarava

    Citation: The Journal of Headache and Pain 2020 21:114

    Content type: Research article

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  12. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yen-Fu Cheng, Sudha Xirasagar, Tzong-Han Yang, Chuan-Song Wu, Yi-Wei Kao, Ben-Chang Shia and Herng-Ching Lin

    Citation: The Journal of Headache and Pain 2020 21:113

    Content type: Correction

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    The original article was published in The Journal of Headache and Pain 2020 21:46

  13. Chronic migraine (CM) can be associated with aberrant long-range connectivity of MRI-derived resting-state networks (RSNs). Here, we investigated how the fractal dimension (FD) of blood oxygenation level depen...

    Authors: Camillo Porcaro, Antonio Di Renzo, Emanuele Tinelli, Giorgio Di Lorenzo, Vincenzo Parisi, Francesca Caramia, Marco Fiorelli, Vittorio Di Piero, Francesco Pierelli and Gianluca Coppola

    Citation: The Journal of Headache and Pain 2020 21:112

    Content type: Research article

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  14. Resting-state functional magnetic resonance imaging (Rs-fMRI) has confirmed sensorimotor network (SMN) dysfunction in migraine without aura (MwoA). However, the underlying mechanisms of SMN effective functiona...

    Authors: Heng-Le Wei, Jing Chen, Yu-Chen Chen, Yu-Sheng Yu, Xi Guo, Gang-Ping Zhou, Qing-Qing Zhou, Zhen-Zhen He, Lian Yang, Xindao Yin, Junrong Li and Hong Zhang

    Citation: The Journal of Headache and Pain 2020 21:111

    Content type: Research article

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  15. Limited studies have measured the burden of migraine in Japan. This study aimed at estimating the disease burden of migraine in Japan and identifying factors associated with the burden using the 2017 National ...

    Authors: Shoji Kikui, Yirong Chen, Hiroshi Todaka, Keiko Asao, Kenji Adachi and Takao Takeshima

    Citation: The Journal of Headache and Pain 2020 21:110

    Content type: Research article

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  16. The long-term safety and efficacy of fremanezumab were evaluated in a 52-week extension study (NCT02638103). Patient satisfaction with fremanezumab, dosing preferences, and patient-reported outcomes were asses...

    Authors: Dawn C. Buse, Sanjay K. Gandhi, Joshua M. Cohen, Verena Ramirez-Campos, Blaine Cloud, Ronghua Yang and Robert P. Cowan

    Citation: The Journal of Headache and Pain 2020 21:109

    Content type: Research article

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  17. The Global Burden of Disease (GBD) study establishes headache as the second-highest cause of disability worldwide. Because most headache data in GBD are from adults, leading to underestimation of headache-attr...

    Authors: Yared Zenebe Zewde, Mehila Zebenigus, Hanna Demissie, Redda Tekle-Haimanot, Derya Uluduz, Tayyar Şaşmaz, Fatma Bozdag and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2020 21:108

    Content type: Research article

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  18. The Global Campaign against Headache collects data from children (7–11 years) and adolescents (12–17 years) both to inform health and education policies and to contribute to the Global Burden of Disease (GBD) ...

    Authors: Otgonbayar Luvsannorov, Tsengunmaa Anisbayar, Munkhzul Davaasuren, Otgonzaya Baatar, Khaliunaa Batmagnai, Khulan Tumurbaatar, Sarantuya Enkhbaatar, Derya Uluduz, Tayyar Şaşmaz, Elif Tuğçe Solmaz and Timothy J. Steiner

    Citation: The Journal of Headache and Pain 2020 21:107

    Content type: Research article

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  19. Previous studies have reported that electrical stimulation of the motor cortex is effective in reducing trigeminal neuropathic pain; however, the effects of optical motor cortex stimulation remain unclear.

    Authors: Jaisan Islam, Elina KC, Byeong Ho Oh, Soochong Kim, Sang-hwan Hyun and Young Seok Park

    Citation: The Journal of Headache and Pain 2020 21:106

    Content type: Research article

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  20. Different pain syndromes may be characterized by different profiles of mediators reflecting pathophysiological differences, and these alterations may be measured in a simple saliva sample. The aims of the curr...

    Authors: Hajer Jasim, Bijar Ghafouri, Björn Gerdle, Britt Hedenberg-Magnusson and Malin Ernberg

    Citation: The Journal of Headache and Pain 2020 21:105

    Content type: Research article

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  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Li Ping Wong, Haridah Alias, Nirmala Bhoo-Pathy, Ivy Chung, Yew Ching Chong, Sonesh Kalra and Zia U. Bahkt Sultan Shah

    Citation: The Journal of Headache and Pain 2020 21:104

    Content type: Correction

    Published on:

    The original article was published in The Journal of Headache and Pain 2020 21:68

  22. Neuropathic pain (NP) is a sustained and nonreversible condition characterized by long-term devastating physical and psychological damage. Therefore, it is urgent to identify an effective treatment for NP. Unf...

    Authors: Binbin Lin, Yuting Wang, Piao Zhang, Yanyan Yuan, Ying Zhang and Gang Chen

    Citation: The Journal of Headache and Pain 2020 21:103

    Content type: Review article

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  23. Most patients treated with erenumab in clinical practice have chronic migraine (CM). We assessed the rate and possible predictors of conversion from CM to episodic migraine (EM) in a real-life study.

    Authors: Raffaele Ornello, Alfonsina Casalena, Ilaria Frattale, Valeria Caponnetto, Amleto Gabriele, Giannapia Affaitati, Maria Adele Giamberardino, Maurizio Assetta, Maurizio Maddestra, Fabio Marzoli, Stefano Viola, Davide Cerone, Carmine Marini, Francesca Pistoia and Simona Sacco

    Citation: The Journal of Headache and Pain 2020 21:102

    Content type: Short report

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  24. Although migraine is one of the most common primary headaches, its therapy is still limited in many cases. The use of animal models is crucial in the development of novel therapeutic strategies, but unfortunat...

    Authors: Klaudia Flóra Laborc, Eleonóra Spekker, Zsuzsanna Bohár, Mónika Szűcs, Gábor Nagy-Grócz, Annamária Fejes-Szabó, László Vécsei and Árpád Párdutz

    Citation: The Journal of Headache and Pain 2020 21:101

    Content type: Methodology

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  25. Psychological distress is highly prevalent among migraineurs during public health emergencies. The coronavirus disease 2019 (nCOV-2019) has created mass panic in China due to its highly contagious by contact a...

    Authors: Mengmeng Ma, Jinghuan Fang, Changling Li, Jiajia Bao, Yang Zhang, Ning Chen, Jian Guo and Li He

    Citation: The Journal of Headache and Pain 2020 21:100

    Content type: Research article

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  26. Migraine is a common and incapacitating condition, with severe impact on the quality of life (QoL) of the afflicted and their families, and negative economic consequences through decreased workforce participat...

    Authors: Amanda Hansson-Hedblom, Isabelle Axelsson, Lena Jacobson, Joakim Tedroff and Fredrik Borgström

    Citation: The Journal of Headache and Pain 2020 21:99

    Content type: Research article

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  27. Previous studies found an association between migraine and dementia, which are two leading causes of disability. However, these studies did not differentiate between migraine types and did not investigate all ...

    Authors: Sabrina Islamoska, Åse Marie Hansen, Hui-Xin Wang, Anne Helene Garde, Per Kragh Andersen, Ellen Garde, Jakob Møller Hansen, Gunhild Waldemar and Kirsten Nabe-Nielsen

    Citation: The Journal of Headache and Pain 2020 21:98

    Content type: Research article

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  28. Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between o...

    Authors: Espen Saxhaug Kristoffersen, Sigrid Børte, Knut Hagen, John-Anker Zwart and Bendik Slagsvold Winsvold

    Citation: The Journal of Headache and Pain 2020 21:97

    Content type: Research article

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  29. Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of t...

    Authors: Nuria García-Magro, Pilar Negredo, Yasmina B. Martin, Ángel Nuñez and Carlos Avendaño

    Citation: The Journal of Headache and Pain 2020 21:96

    Content type: Research article

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  30. We performed a post hoc, subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled study of erenumab for prevention of episodic migraine (STRIVE) to determine the efficacy and safety of eren...

    Authors: Jelena M. Pavlovic, Koen Paemeleire, Hartmut Göbel, Jo Bonner, Alan Rapoport, Risa Kagan, Feng Zhang, Hernan Picard and Daniel D. Mikol

    Citation: The Journal of Headache and Pain 2020 21:95

    Content type: Research article

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  31. Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if pati...

    Authors: Javier Trigo, David García-Azorín, Álvaro Planchuelo-Gómez, Enrique Martínez-Pías, Blanca Talavera, Isabel Hernández-Pérez, Gonzalo Valle-Peñacoba, Paula Simón-Campo, Mercedes de Lera, Alba Chavarría-Miranda, Cristina López-Sanz, María Gutiérrez-Sánchez, Elena Martínez-Velasco, María Pedraza, Álvaro Sierra, Beatriz Gómez-Vicente…

    Citation: The Journal of Headache and Pain 2020 21:94

    Content type: Research article

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  32. Post-traumatic headache (PTH) is one of the most frequent symptoms following mild traumatic brain injury (mTBI). Neuroimaging studies implicate hypothalamic function connectivity (FC) disruption as an importan...

    Authors: Liyan Lu, Fengfang Li, Peng Wang, Huiyou Chen, Yu-Chen Chen and Xindao Yin

    Citation: The Journal of Headache and Pain 2020 21:93

    Content type: Research article

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  33. We investigated intracerebral fiber bundles using a tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) data to verify microstructural integrity in patients with episodic (MO) and ...

    Authors: Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Barbara Petolicchio, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Francesca Caramia, Vittorio Di Piero and Francesco Pierelli

    Citation: The Journal of Headache and Pain 2020 21:92

    Content type: Research article

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  34. Trigeminal neuralgia (TN) is an orofacial condition defined by reoccurring, spontaneous, short-lived but excruciating stabbing pain. Pharmacological interventions constitute the first-line treatment for TN, wi...

    Authors: Rachel O. Coats, Kirsty L. Crossley, Naomi Conlin, Jianhua Wu, Joanna M. Zakrzewska, Sue H. Pavitt, Nicholas Phillips and Mark Mon-Williams

    Citation: The Journal of Headache and Pain 2020 21:91

    Content type: Research article

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  35. According to the International Classification of Headache Disorders 3, post-traumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary headache reported to have developed within 7 days ...

    Authors: Silvia Benemei, Alejandro Labastida-Ramírez, Ekaterina Abramova, Nicoletta Brunelli, Edoardo Caronna, Paola Diana, Roman Gapeshin, Maxi Dana Hofacker, Ilaria Maestrini, Enrique Martínez Pías, Petr Mikulenka, Olga Tikhonova, Paolo Martelletti and Antoinette MaassenVanDenBrink

    Citation: The Journal of Headache and Pain 2020 21:90

    Content type: Review article

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  36. Voxel-based morphometry (VBM) is a popular non-invasive magnetic resonance imaging technique to investigate brain gray matter (GM) differences between groups. Recently, two VBM studies in migraine have been pu...

    Authors: Hong Zhou Wang, Wan Hua Wang, Hai Cun Shi and Cong Hu Yuan

    Citation: The Journal of Headache and Pain 2020 21:89

    Content type: Commentary

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  37. There is a need to establish which are the more relevant headache-related outcomes that have an impact on our patient’s lives to accurately evaluate treatment response in daily clinical practice.

    Authors: Marta Torres-Ferrus, Victor José Gallardo, Alicia Alpuente and Patricia Pozo-Rosich

    Citation: The Journal of Headache and Pain 2020 21:88

    Content type: Research article

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  38. Stimulation of trigeminovascular pathway is widely used to establish the headache animal model. Headache is a common neurological disorder, in which symptomatic attacks are mediated by calcitonin-gene-related ...

    Authors: Ya-Tin Lin, Zachary Yu, Sze-Chi Tsai, Po-Hung Hsu and Jin-Chung Chen

    Citation: The Journal of Headache and Pain 2020 21:87

    Content type: Short report

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  39. Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarizati...

    Authors: Andrea Negro, Jessica L. Seidel, Thijs Houben, Esther S. Yu, Ike Rosen, Andrea J. Arreguin, Nilufer Yalcin, Lea Shorser-Gentile, Lea Pearlman, Homa Sadhegian, Ramalingam Vetrivelan, Nancy L. Chamberlin, Cenk Ayata, Paolo Martelletti, Michael A. Moskowitz and Katharina Eikermann-Haerter

    Citation: The Journal of Headache and Pain 2020 21:86

    Content type: Research article

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  40. Migraine is a frequent headache disorder with high disease burden. The aims of this study were to determine the administrative prevalence and incidence of migraine in Germany; and to elucidate disease characte...

    Authors: Tatjana Roessler, Juergen Zschocke, Anne Roehrig, Michael Friedrichs, Heiko Friedel and Zaza Katsarava

    Citation: The Journal of Headache and Pain 2020 21:85

    Content type: Research article

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  41. Calcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding ef...

    Authors: Armin Scheffler, Olga Messel, Sebastian Wurthmann, Michael Nsaka, Christoph Kleinschnitz, Martin Glas, Steffen Naegel and Dagny Holle

    Citation: The Journal of Headache and Pain 2020 21:84

    Content type: Research article

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  42. Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA recepto...

    Authors: Diego Currò, Pierluigi Navarra, Irene Samengo and Maria Martire

    Citation: The Journal of Headache and Pain 2020 21:83

    Content type: Research article

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  43. Trigeminal neuralgia (TN) is a severe, disabling form of painful cranial neuropathy. Even though TN has a typical clinical picture, diagnosis it is often missed or delayed in clinical practice. In order to inv...

    Authors: F. Antonaci, S. Arceri, M. Rakusa, D. D. Mitsikostas, I. Milanov, V. Todorov, M. Cotta Ramusino and A. Costa

    Citation: The Journal of Headache and Pain 2020 21:82

    Content type: Research article

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  44. Many studies have described the features of menstrually-related migraines (MRM) in the natural cycle and the efficacy of prevention. MRM in combined hormonal contraceptive (CHC) users has scarcely been researc...

    Authors: Gabriele S. Merki-Feld, Nina Caveng, Gina Speiermann and E. Anne MacGregor

    Citation: The Journal of Headache and Pain 2020 21:81

    Content type: Research article

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  45. Primary headache disorders have being increasingly reported in younger populations. They can have significant effects on their quality of life and academic achievement and may cause significant distress to the...

    Authors: Jasem Y. Al-Hashel, R. Alroughani, S. Shauibi, A. AlAshqar, F. AlHamdan, H. AlThufairi, S. Owayed and Samar F. Ahmed

    Citation: The Journal of Headache and Pain 2020 21:80

    Content type: Research article

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  46. Migraine clinical profile may change with age, making it necessary to verify that migraine treatments are equally safe and effective in older patients. These analyses evaluated the effects of patient age on th...

    Authors: Virginia L. Stauffer, Ira Turner, Phebe Kemmer, William Kielbasa, Kathleen Day, Martha Port, Tonya Quinlan and Angelo Camporeale

    Citation: The Journal of Headache and Pain 2020 21:79

    Content type: Research article

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  47. Chronic pain surrounding the temporomandibular joints and masticatory muscles is often the primary chief complaint of patients with temporomandibular disorders (TMD) seeking treatment. Yet, the neuro-pathophys...

    Authors: Yuanyuan Yin, Shushu He, Jingchen Xu, Wanfang You, Qian Li, Jingyi Long, Lekai Luo, Graham J. Kemp, John A. Sweeney, Fei Li, Song Chen and Qiyong Gong

    Citation: The Journal of Headache and Pain 2020 21:78

    Content type: Review article

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  49. Despite advances in the management of headache disorders, some patients with migraine do not experience adequate pain relief with acute and preventive treatments. It is the aim of the present document to provi...

    Authors: Simona Sacco, Mark Braschinsky, Anne Ducros, Christian Lampl, Patrick Little, Antoinette Maassen van den Brink, Patricia Pozo-Rosich, Uwe Reuter, Elena Ruiz de la Torre, Margarita Sanchez Del Rio, Alexandra J. Sinclair, Zaza Katsarava and Paolo Martelletti

    Citation: The Journal of Headache and Pain 2020 21:76

    Content type: Consensus article

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  50. This study evaluates the accuracy of an automated classification tool of single attacks of the two major primary headache disorders migraine and tension-type headache used in an electronic headache diary.

    Authors: Aaron Roesch, Markus A Dahlem, Lars Neeb and Tobias Kurth

    Citation: The Journal of Headache and Pain 2020 21:75

    Content type: Research article

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