Table 3 Effects of Lu AG09222 following VIP infusion^a

Superficial temporal artery diameter

 AUC_STA-VIP, mm × min, mean (SD)

4.06 (5.47)

22.7 (11.4)

16.5 (12.4)

  LS mean difference (SE) [95% CI]

18.1 (6.10) [4.68, 31.5]

‒6.49 (6.82) [‒20.9, 7.97]

  P-value

0.0128^b

0.3555^c

 CFI_{STA-60 min-VIP}, mm, mean (SD)

0.047 (0.050)

0.188 (0.110)

0.144 (0.122)

  LS mean difference (SE) [95% CI]

‒0.045 (0.068) [‒0.188, 0.099]

  P-value

0.5173^c

 max_STA-VIP, mm, mean (SD)

0.071 (0.051)

0.405 (0.107)

0.274 (0.208)

  LS mean difference (SE) [95% CI]

‒0.124 (0.091) [‒0.316, 0.068]

  P-value

0.1894^c

Radial artery diameter

 AUC_RA-VIP, mm × min, mean (SD)

‒1.09 (4.34)

1.23 (6.49)

9.31 (6.24)

  LS mean difference (SE) [95% CI]

1.16 (3.69) [‒6.95, 9.28]

11.6 (2.83) [5.59, 17.6]

  P-value

0.7578^b

 CFI_{RA-60 min-VIP}, mm, mean (SD)

0.006 (0.045)

0.017 (0.066)

0.075 (0.052)

  LS mean difference (SE) [95% CI]

0.077 (0.030) [0.013, 0.141]

 max_RA-VIP, mm, mean (SD)

0.034 (0.23)

0.087 (0.097)

0.135 (0.062)

  LS mean difference (SE) [95% CI]

0.0773 (0.0403) [‒0.00811, 0.163]

Facial blood flow

 AUC_FBF-VIP, flux × min, mean (SD)

‒1216 (4420)

11,919 (6959)

9827 (10,983)

  LS mean difference (SE) [95% CI]

12,865 (3129) [5977, 19,752]

‒3210 (4337) [‒12,400, 5985]

  P-value

0.0017^b

0.4701^c

 max_FBF-VIP, flux, mean (SD)

55.4 (31.0)

366 (169)

199 (99.8)

  LS mean difference (SE) [95% CI]

–214 (53.6) [–328, –100]

  P-value

0.0011^c

Heart rate

 AUC_HR-VIP, beats, mean (SD)

14.8 (524)

897 (560)

585 (568)

  LS mean difference (SE) [95% CI]

853 (295) [203, 1502]

–271 (215) [–728, 186]

  P-value

0.0147^b

0.2265^c

Headache intensity

 AUC_{HI-VIP 0-8 h}, points, mean (SD)

35.9 (80.3)

104 (178)

88.4 (179)

  LS mean difference (SE) [95% CI]

-15.2 (82.2) [–189, 158]

  P-value

0.8554^c

 max_HI-VIP, points, mean (SD)

0.400 (0.894)

1.10 (0.994)

0.800 (1.87)

  LS mean difference (SE) [95% CI]

-0.300 (0.690) [–1.76, 1.16]

  P-value

0.6692^c