Fig. 4

Effects of estradiol replacement and withdrawal in castrated rats on CSD susceptibility. CSD frequency, speed, duration, and amplitude are shown for castrated rats after 3 weeks of vehicle treatment (Cst + V, n = 7), castrated rats after 3 weeks of 50 μg/kg/day β-estradiol-3-benzoate treatment (Cst + E, n = 6) and castrated rats treated with 50 μg/kg/day β-estradiol-3-benzoate for 2 weeks followed by withdrawal (Cst + E/W, n = 7)