Fig. 6

TNF-alpha gene expression (expressed as relative quantification (RQ)) in medulla in toto, cervical spinal cord (CSC) and Trigeminal ganglion (TG) ipsilateral to formalin injection and in meninges in the acute migraine model. Data were normally distributed and were analyzed using one-way ANOVA followed by Tukey's multiple comparisons test: *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 vs. CT; °p < 0.05, °°p < 0.01 and °°°°p < 0.0001 vs. NTG; #p < 0.05, ###p < 0.001 and ####p < 0.0001 vs. CBD 15 mg; ^p < 0.05, ^^p < 0.01, ^^^p < 0.001 and ^^^^p < 0.0001 vs. CBD 30 mg; §p < 0.05 vs. NTG + CBD 15 mg. Data are expressed as mean ± SEM, N = 7–8 per group