- The thickness of the PSD, the width of the synaptic cleft, synaptic interface curvature, and active zones in the CM group significantly increased compared with those in the Sham group, while treatment with NE or ZD 7288 reversed the changes. There was no statistical change between the CM and CM + Vehicle groups. Data are presented as the mean ± SEM. (n = 6/group, **p < 0.01, vs Sham group; ##p < 0.01, vs CM + Vehicle group)