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Fig. 7 | The Journal of Headache and Pain

Fig. 7

From: Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model

Fig. 7

The effect of ZD 7288 on the pNR2B/CaMKII/pCREB pathway in CM rats. A Representative western blots of pNR2B, CaMKII, pCREB, tNR2B, and tCREB. B-D Compared with the Sham group, the levels of pNR2B, CaMKII, and pCREB in the CM group were profoundly elevated, and there was no change between CM and CM + Vehicle groups. Compared to the CM + Vehicle group, the levels of pNR2B, CaMKII, and pCREB in the CM + ZD 7288 group were visibly decreased. (n = 6/group, **p < 0.01, N, S, not significant). E and F There was no significant difference in tNR2B and tCREB expression among the Sham, CM, CM + Vehicle, and CM + ZD 7288 groups. (n = 6/group, N, S, not significant)

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The Journal of Headache and Pain

ISSN: 1129-2377

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