Fig. 2From: Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat modelThe influence of repeated dural IS stimulation on hyperalgesia in CM rats. A and B Compared with the Sham group treated with PBS infusion, the mechanical pain thresholds of the periorbital region and hindpaw in the CM group treated with IS infusion markedly reduced after the second day. (n = 10/group, **p < 0.01, vs Sham). C The thermal pain thresholds of the hindpaw in the CM group were visibly lower than those in the Sham group after the second day. (n = 10/group, **p < 0.01, vs Sham)Back to article page