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Fig. 12 | The Journal of Headache and Pain

Fig. 12

From: Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model

Fig. 12

Schematic diagrams of CB1R-mediated regulation on central sensitization. A In CM, activation of CB1 inhibits HCN2 activity by reducing cAMP levels, thereby suppressing the pNR2B/CaMKII/pCREB pathway. B A decrease in intranuclear pCREB level alleviates central sensitization by regulating expression levels of synaptic proteins (PSD95 and SYP) and nociceptive transmitters (SP and CGRP) in CM

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The Journal of Headache and Pain

ISSN: 1129-2377

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