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Table 3 The correlation between FC and clinical characteristics in patients with NDPH

From: Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study

Brain regions

Side

Disease duration

r (p-value)

VAS score

r (p-value)

HIT-6 score

r (p-value)

PHQ-9 score

r (p-value)

GAD-7 score

r (p-value)

PSQI score

r (p-value)

MoCA score

r (p-value)

Seed: right lingual gyrus; FC: patients < HCs

 Cluster 1

  Calcarine

R

0.070 (0.719)

-0.079 (0.686)

0.036 (0.086)

-0.195 (0.339)

0.013 (0.948)

0.256 (0.217)

-0.074 (0.772)

  Fusiform gyrus

R

-0.032 (0.870)

0.048 (0.804)

0.120 (0.569)

-0.244 (0.230)

0.114 (0.579)

-0.017 (0.936)

-0.071 (0.780)

  Calcarine

L

-0.118 (0.544)

-0.046 (0.814)

-0.137 (0.514)

-0.269 (0.183)

0.014 (0.947)

0.056 (0.792)

0.137 (0.587)

Seed: left superior occipital gyrus; FC: patients < HCs

 Cluster 1

  Lingual gyrus

R

0.205 (0.287)

0.033 (0.865)

0.217 (0.297)

-0.241 (0.236)

0.065 (0.763)

0.185 (0.377)

-0.195 (0.435)

  Fusiform gyrus

R

0.039 (0.839)

0.006 (0.977)

0.030 (0.886)

-0.228 (0.263)

0.120 (0.559)

0.015 (0.945)

0.030 (0.905)

Seed: right middle occipital gyrus; FC: patients < HCs

 Cluster 1

  Lingual gyrus

R

0.234 (0.221)

0.116 (0.549)

0.242 (0.243)

-0.277 (0.270)

0.077 (0.710)

0.021 (0.922)

-0.137 (0.586)

  Lingual gyrus

L

0.198 (0.303)

0.070 (0.718)

0.276 (0.181)

-0.265 (0.190)

0.081 (0.693)

0.101 (0.630)

-0.069 (0.786)

  Calcarine

R

0.185 (0.335)

0.051 (0.792)

0.268 (0.194)

-0.322 (0.109)

0.022 (0.915)

-0.056 (0.790)

-0.008 (0.975)

  Fusiform gyrus

R

0.049 (0.803)

0.102 (0.598)

0.057 (0.787)

-0.188 (0.358)

0.160 (0.435)

0.037 (0.862)

0.319 (0.397)

Seed: left inferior occipital gyrus; FC: patients > HCs

 Cluster 1

  Superior frontal gyrus, medial

R

0.023 (0.907)

0.192 (0.319)

0.158 (0.452)

-0.019 (0.925)

0.236 (0.247)

0.093 (0.660)

0.104 (0.681)

Seed: left inferior occipital gyrus; FC: patients < HCs

 Cluster 1

  Lingual gyrus

L

-0.038 (0.845)

-0.010 (0.961)

0.254 (0.220)

-0.257 (0.204)

-0.029 (0.889)

-0.025 (0.907)

-0.209 (0.406)

  Fusiform gyrus

L

-0.054 (0.779)

0.143 (0.461)

0.112 (0.594)

-0.184 (0.369)

0.126 (0.540)

0.068 (0.746)

0.032 (0.898)

  Inferior occipital gyrus

L

0.017 (0.932)

0.033 (0.864)

-0.009 (0.966)

0.258 (0.203)

0.099 (0.630)

-0.009 (0.967)

-0.084 (0.739)

 Cluster 2

  Middle occipital gyrus

R

0.312 (0.100)

0.054 (0.780)

0.225 (0.279)

-0.175 (0.392)

0.131 (0.525)

0.160 (0.444)

-0.144 (0.568)

  Lingual gyrus

R

-0.017 (0.931)

0.065 (0.738)

0.207 (0.321)

-0.280 (0.166)

-0.099 (0.631)

0.028 (0.895)

0.106 (0.675)

  Inferior occipital gyrus

R

0.104 (0.593)

0.114 (0.555)

-0.111 (0.597)

-0.288 (0.154)

0.028 (0.892)

-0.034 (0.873)

-0.326 (0.186)

Seed: right inferior occipital gyrus; FC: patients < HCs

 Cluster 1

  Lingual gyrus

L

0.046 (0.813)

0.010 (0.958)

0.297 (0.150)

0.246 (0.226)

0.017 (0.936)

-0.124 (0.555)

0.053 (0.833)

  Fusiform gyrus

L

0.050 (0.797)

0.003 (0.986)

0.125 (0.552)

0.254 (0.210)

0.049 (0.812)

0.151 (0.471)

0.124 (0.624)

  Inferior occipital gyrus

L

0.069 (0.721)

0.077 (0.691)

-0.051 (0.807)

0.265 (0.191)

0.027 (0.894)

0.027 (0.897)

0.184 (0.464)

 Cluster 2

  Lingual gyrus

R

0.058 (0.765)

0.067 (0.730)

0.231 (0.266)

0.265 (0.191)

0.059 (0.773)

0.111 (0.596)

-0.078 (0.759)

  Fusiform gyrus

R

-0.093 (0.633)

0.130 (0.500)

0.142 (0.499)

-0.186 (0.364)

0.080 (0.698)

0.031 (0.884)

0.126 (0.618)

Seed: right fusiform gyrus; FC: patients < HCs

 Cluster 1

  Lingual gyrus

R

0.092 (0.634)

0.106 (0.586)

0.234 (0.261)

-0.190 (0.354)

0.069 (0.737)

0.126 (0.548)

-0.105 (0.679)

  Lingual gyrus

L

0.088 (0.648)

0.013 (0.947)

0.204 (0.328)

-0.219 (0.283)

0.084 (0.684)

0.083 (0.695)

-0.018 (0.943)

  Inferior occipital gyrus

R

0.054 (0.782)

0.153 (0.429)

0.115 (0.584)

-0.204 (0.317)

0.014 (0.944)

-0.012 (0.956)

-0.315 (0.203)

  Calcarine

R

0.077 (0.690)

-0.004 (0.982)

0.283 (0.171)

0.189 (0.354)

0.017 (0.934)

0.134 (0.524)

-0.102 (0.687)

 Cluster 2

  Cuneus

R

0.245 (0.201)

-0.002 (0.992)

0.286 (0.165)

-0.245 (0.227)

0.047 (0.819)

0.005 (0.981)

0.034 (0.894)

  Superior occipital gyrus

R

0.156 (0.420)

-0.166 (0.510)

0.213 (0.306)

-0.15 (0.465)

0.075 (0.718)

0.144 (0.492)

-0.166 (0.510)

Seed: left postcentral gyrus; FC: patients < HCs

 Cluster 1

  Postcentral gyrus

R

0.176 (0.361)

0.286 (0.132)

0.042 (0.842)

-0.134 (0.514)

0.211 (0.300)

-0.009 (0.967)

0.074 (0.771)

  Precentral gyrus

R

-0.010 (0.959)

0.232 (0.225)

0.051 (0.810)

-0.154 (0.453)

0.081 (0.695)

-0.031 (0.885)

0.090 (0.722)

Seed: right postcentral gyrus; FC: patients < HCs

 Cluster 1

  Postcentral gyrus

L

0.113 (0.559)

0.178 (0.355)

0.002 (0.991)

0.226 (0.267)

0.141 (0.492)

-0.069 (0.742)

-0.078 (0.757)

  Precentral gyrus

L

-0.011 (0.956)

0.176 (0.362)

0.021 (0.920)

-0.213 (0.296)

-0.081 (0.695)

-0.113 (0.692)

0.189 (0.452)

 Cluster 2

  Precentral gyrus

R

-0.092 (0.635)

0.225 (0.231)

-0.072 (0.731)

-0.171 (0.404)

0.016 (0.939)

0.201 (0.425)

0.229 (0.231)

Seed: right thalamus; FC: patients > HCs

 Cluster 1

  Cuneus

L

-0.173 (0.370)

-0.062 (0.750)

0.208 (0.319)

0.237 (0.243)

0.118 (0.566)

-0.043 (0.839)

-0.015 (0.952)

  Cuneus

R

-0.136 (0.483)

-0.071 (0.713)

0.166 (0.427)

0.232 (0.255)

0.075 (0.716)

-0.055 (0.794)

-0.087 (0.731)

  Calcarine

L

0.183 (0.343)

0.062 (0.751)

0.195 (0.349)

-0.107 (0.602)

0.157 (0.445)

0.008 (0.971)

0.023 (0.928)

  Superior occipital gyrus

R

-0.018 (0.924)

0.121 (0.531)

0.330 (0.107)

0.176 (0.389)

0.122 (0.554)

0.014 (0.949)

-0.231 (0.356)

Seed: right superior temporal gyrus; FC: patients < HCs

 Cluster 1

  Postcentral gyrus

R

-0.074 (0.704)

0.289 (0.129)

0.252 (0.223)

0.018 (0.932)

0.183 (0.370)

0.042 (0.842)

0.339 (0.169)

  Rolandic operculum

R

0.042 (0.828)

0.371 (0.048)

0.350 (0.087)

-0.083 (0.688)

0.088 (0.688)

0.220 (0.290)

0.220 (0.380)

  1. Abbreviations: HCs healthy controls, VAS visual analogue scale, HIT-6 headache impact test, PHQ-9 patient health questionnaire-9, GAD-7 generalized anxiety disorder-7, PSQI Pittsburgh sleep quality index, MoCA Montreal cognitive assessment. Statistical significance: p < 0.00019 (Bonferroni correction)