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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model

Fig. 2

Global loss of PAR2 and administration of sumatriptan inhibits dural 2AT-induced hypersensitivity. A Facial withdrawal thresholds in male PAR2KO mice and their WT controls following treatment with either 2AT or vehicle. WT male mice administered 2AT (n = 7) exhibited significantly decreased withdrawal thresholds compared PAR2KO mice treated with 2AT (n = 7) and both WT (n = 4) and PAR2KO (n = 6) mice treated with vehicle. B Facial withdrawal thresholds in female PAR2KO mice and their WT controls following treatment with either 2AT or vehicle. WT female mice administered 2AT (n = 7) exhibited significantly decreased withdrawal thresholds compared PAR2KO mice treated with 2AT (n = 8) and both WT (n = 7) and PAR2KO (n = 6) mice treated with vehicle. C Grimace scores of male PAR2KO mice and their WT controls following dural application of either 2-AT or vehicle. WT male mice administered 2AT exhibited significantly increased grimacing compared to PAR2KO mice treated with 2AT and both WT and PAR2KO mice treated with vehicle. D Grimace scores of female PAR2KO mice and their WT controls following dural application of either 2AT or vehicle. WT female mice administered 2AT exhibited significantly increased grimacing compared to PAR2KO mice treated with 2AT and both WT and PAR2KO mice treated with vehicle. E Facial withdrawal thresholds in male WT mice administered 2AT and sumatriptan. Sumatriptan significantly attenuates withdrawal thresholds induced by 2AT (2AT + Suma; n = 5) compared to 2AT + Veh (n = 6) F Facial withdrawal thresholds in female WT mice administered 2AT and sumatriptan. Sumatriptan significantly attenuates withdrawal thresholds induced by 2AT (2AT + Suma; n = 7) compared to 2AT + Veh (n = 7). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Data are represented as mean ± SEM

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