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Table 3 Plasma concentrations of Trp metabolites in healthy controls and cluster headache patients in both interbout and ictal periods

From: Cluster headache and kynurenines

Metab. (nM)

Groups: Median ± IQR

p-values between groups

1. Healthy Control (n = 22)

2. Cluster Interbout (n = 13)

3. Cluster Ictal (n = 11)

Trp

57,737.78 ± 21,948.78

57,696.19 ± 20,535.86

49,724.64 ± 16,000.00

0.839

KYN

2059.42 ± 720.39

1668.05 ± 570.59

1462.54 ± 578.66

1–3: 0.006

KYNA

43.56 ± 26.30

41.56 ± 25.90

32.60 ± 14.11

0.183

ANA

44.18 ± 34.48

35.25 ± 23.61

28.12 ± 19.57

0.164

3-HK

41.03 ± 15.78

44.31 ± 16.11

33.92 ± 35.60

0.643

XA

15.41 ± 10.81

16.00 ± 10.86

11.80 ± 8.97

0.247

3-HANA

49.18 ± 32.17

53.61 ± 32.98

45.60 ± 23.86

0.779

PICA

48.20 ± 34.74

39.01 ± 27.71

31.43 ± 16.69

0.259

QUINA

431.58 ± 233.42

453.82 ± 206.39

403.35 ± 109.50

1–2: 0.015

5-HT

43.72 ± 311.28

221.98 ± 360.68

366.25 ± 412.22

0.070

5-HIAA

42.59 ± 21.55

46.71 ± 10.66

43.21 ± 12.89

0.124

  1. All p-values were added in the table between control and headache periods of cluster patients. Significant differences were revealed between control and ictal data in case of KYN and between control and interbout data in case of QUINA
  2. IQR interquartile range, Metab metabolites, Trp Tryptophan, KYN L-kynurenine, KYNA Kynurenic acid, ANA Anthranilic acid, 3-HK 3-hydroxikynurenine, XA Xanthurenic acid, 3-HANA 3-hydroxianthranilic acid, PICA Picolinic acid, QUINA Quinolinic acid, 5-HT 5-hydroxytryptamine, 5-HIAA 5-hydroxiindoleaceticacid