Fig. 1
From: Shared and independent roles of CGRP and PACAP in migraine pathophysiology
Clinical symptoms caused by CGRP and PACAP infusions. Both CGRP and PACAP cause migraine-like headache in about 2/3 of migraine patients. PACAP causes more premonitory symptoms and side effects than CGRP. Data are only from studies that included premonitory symptoms [37, 38, 41]. For a comprehensive listing of CGRP and PACAP infusion studies and migraine frequencies, see Table 1. Created with BioRender.com