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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

Fig. 3

Effect of dual MAGL-FAAH inhibitor AKU-005 on rat meningeal fibres. A Example traces of control basal and AKU-005 (100 nM) induced activity in rat meningeal fibres. B Statistics show lightly increased general excitability in the presence of AKU-005 as evidenced by an increasing number of APs for the 10-min application window in the presence of AKU-005 (AKU) (N = 19, Wilcoxon test) compared to the control condition (Cntr) (N = 19, Wilcoxon test, ** = 0.002)

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