Table 2 Univariate and multivariate analyses of determinants of ≥ 50% response

Patient characteristics

Age

1.050 (1.015 ~ 1.087)

0.005

1.072 (1.025 ~ 1.121)

0.002

Onset age

1.018 (0.985 ~ 1.052)

0.292

Sex

1.632 (0.585 ~ 4.553)

0.350

BMI

1.019 (0.921 ~ 1.128)

0.717

Migriane characteristics

Chronic Migraine

0.524 (0.236 ~ 1.163)

0.112

Aura

0.967 (0.395 ~ 2.368)

0.942

Unilateral pain

0.789 (0.33 ~ 1.886)

0.594

Pulsating pain

1.026 (0.455 ~ 2.312)

0.951

Pain severity

1.003 (0.775 ~ 1.299)

0.980

Duration

0.935 (0.866 ~ 1.01)

0.086

0.965 (0.871 ~ 1.070)

0.502

Aggravation by routine physical activity

1.095 (0.403 ~ 2.976)

0.859

MHD

0.942 (0.893 ~ 0.994)

0.029

0.948 (0.884 ~ 1.017)

0.137

MMD

0.96 (0.91 ~ 1.013)

0.139

AMD

0.985 (0.932 ~ 1.04)

0.586

MOH

0.523 (0.217 ~ 1.264)

0.150

Associated symptoms

Photophobia—none

- mild

2.167 (0.706 ~ 6.645)

0.176

1.813 (0.442 ~ 7.439)

0.409

- moderate

2.758 (0.900 ~ 8.453)

0.076

3.098 (0.754 ~ 12.726)

0.117

- severe

1.011 (0.279 ~ 3.66)

0.987

1.233 (0.235 ~ 6.466)

0.804

Phonophobia—none

- mild

1.6 (0.547 ~ 4.681)

0.391

- moderate

1.477 (0.485 ~ 4.497)

0.492

- severe

1.8 (0.476 ~ 6.813)

0.387

Nausea/vomitting—none

- mild

0.574 (0.213 ~ 1.549)

0.273

- moderate

1.2 (0.407 ~ 3.536)

0.741

- severe

2.933 (0.287 ~ 30.007)

0.364

Treatment

Triptan response (/3 times)—0

- 1

2.5 (0.622 ~ 10.049)

0.197

2.133 (0.410 ~ 11.083)

0.368

- 2

4.722 (1.149 ~ 19.407)

0.031

3.221 (0.585 ~ 17.718)

0.179

- 3

4.375 (1.124 ~ 17.033)

0.033

1.340 (0.260 ~ 6.918)

0.727

Total prior treatment failures

0.675 (0.46 ~ 0.99)

0.044

0.512 (0.290 ~ 0.904)

0.021

Other scores

GAD-7

0.986 (0.892 ~ 1.089)

0.774

PHQ-9

1.028 (0.934 ~ 1.131)

0.579

Medical history

Psychiatric

0.867 (0.358 ~ 2.096)

0.751

Gastrointestinal

0.967 (0.395 ~ 2.368)

0.942

Vascular

0.473 (0.107 ~ 2.097)

0.324

Hormonal

1.433 (0.324 ~ 6.349)

0.635

Cancer

1.004 (0.286 ~ 3.531)

0.995

Respiratory

1.531 (0.419 ~ 5.598)

0.519

Immuno-rheumatologic

0.123 (0.014 ~ 1.066)

0.057

0.027 (0.002 ~ 0.422)

0.010

Family history of headache

0.467 (0.207 ~ 1.051)

0.066

0.577 (0.196 ~ 1.700)

0.318