Fig. 4

LOO sensitivity analysis. A Forward LOO sensitivity analysis for the OD in right posterior thalamic radiation (IDP 2005). B Reverse LOO sensitivity analysis for the OD in left superior cerebellar peduncle (IDP 1990). Each black point represents the IVW causal estimates after excluding the respective SNP from the analysis, and the error bars represent 95% CI. The red point represents the IVW causal estimates using all SNPs, and the error bars represent 95% CI. There is no dramatic change in causal estimates after excluding one particular SNP. Abbreviations: IDP, imaging-derived phenotypes; IVW, inverse variance-weighted; LOO, leave-one-out; OR, odds ratio