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Table 2 Enriched KEGG pathways of predicted target from the 3-miRNA differentially expressed signature

From: A study of differential microRNA expression profile in migraine: the microMIG exploratory study

ID

KEGG Pathway

Adj. p-value

Target genes

hsa04020

Calcium signaling pathway

 < 0.0001

CACNA1C, HTR2C, PRKCA

hsa04330

Notch signaling pathway

0.001

DTX4, EP300

hsa04750

Inflammatory mediator regulation of TRP channels

0.002

HTR2C, PTGER4, PRKCA

hsa04720

Long-term potentiation

0.002

CACNA1C, EP300, PRKCA

hsa05031

Amphetamine addiction

0.003

CACNA1C, PRKCA

hsa04540

Gap junction

0.005

HTR2C, PRKCA

hsa04350

TGF-beta signaling pathway

0.006

ID2, ID4, EP300

hsa04912

GnRH signaling pathway

0.006

PRKCA, CACNA1C

hsa04713

Circadian entrainment

0.007

CACNA1C, PRKCA

hsa04925

Aldosterone synthesis and secretion

0.007

PRKCA, CACNA1C

hsa04916

Melanogenesis

0.008

EP300, PRKCA

hsa04066

HIF-1 signaling pathway

0.010

EP300, PRKCA

hsa04726

Serotonergic synapse

0.011

CACNA1C, HTR2C, PRKCA

hsa04935

Growth hormone synthesis, secretion and action

0.013

EP300, PRKCA, CACNA1C

hsa04919

Thyroid hormone signaling pathway

0.014

EP300, PRKCA

hsa04270

Vascular smooth muscle contraction

0.015

CACNA1C, PRKCA

hsa04728

Dopaminergic synapse

0.018

PRKCA, CACNA1C

hsa04261

Adrenergic signaling in cardiomyocytes

0.025

CACNA1C, PRKCA

hsa04921

Oxytocin signaling pathway

0.027

PRKCA, CACNA1C

hsa04150

mTOR signaling pathway

0.028

RICTOR, PRKCA

hsa05161

Hepatitis B

0.033

EP300, PRKCA

hsa04310

Wnt signaling pathway

0.034

EP300, PRKCA

hsa05164

Influenza A

0.039

EP300, PRKCA

hsa05152

Tuberculosis

0.046

EP300, EEA1

  1. Adj. p-value are the lowest enrichment p-value obtained through multiple iterations. The target genes are the predicted genes (targets of at least one DE miRNA) involved in the given enriched pathway
  2. KEGG Kyoto Encyclopedia of Genes and Genomes, Adj. p-value adjusted p-value corrected for multi-testing using the Benjamini–Hochberg procedure (FDR)