A study of differential microRNA expression profile in migraine: the microMIG exploratory study

Table 1 Demographics, life habits, comorbidities and migraine characteristics

	HC (n = 12)	Migraine (n = 18)	P value
Demographics
Age, years	30.0 [28.0, 33.5]	36.0 [28.2, 41.0]	0.319^‡
Body mass index, kg/m²	22.7 [21.7, 23.2]	22.9 [20.4, 25.5]	0.594^†
Life-habits
IPAQ-SF, METs/week	3.1 [2.2, 4.2]	3.4 [1.4, 6.2]	0.750^‡
Caffeine consumption, g/week	1.1 [0.9, 1.6]	1.0 [0.2, 1.4]	0.261^†
Alcohol consumption, g/week	15.0 [0.0, 40.0]	0.0 [0.0, 10.0]	0.062^‡
Comorbidities
Anxiety (STAI), score
State	35.0 [32.0, 41.0]	38.5 [36.2, 52.2]	0.075^†
Trait	31.0 [27.0, 38.2]	39.5 [37.2, 55.8]	0.007^†
Depression (BDI-II), score	4.0 [0.8, 6.2]	8.5 [1.2, 14.8]	0.232^‡
Perceived stress (PSS), score	16.0 [12.8, 22.5]	19.5 [17.0, 32.0]	0.270^†
Migraine characteristics
Duration of migraine disease, y		19.5 [11.0, 27.0]
Aura		38.9% (7)
Allodynia		72.2% (13)
ASC-12, score		4.5 [2.2, 6.0]
Monthly headache frequency, d/mo		10.5 [8.0, 24.2]
Monthly acute medication intake, d/mo		7.5 [4.0, 9.0]
Migraine-related clinical burden
Disability (MIDAS), score		28.5 [17.2, 47.8]
Headache-related impact (HIT-6), score		63.5 [61.2, 69.0]

Continuous data is represented in median [IQR] and categorical data in % (n).
Bold font indicates statistically significant variables
IQR: interquartile range, HC healthy controls, y years, IPAQ-SF short-form of the international physical activity questionnaire, MET metabolic equivalents of task, STAI State-Trait Anxiety Inventory, BDI-II Beck depression inventory-second edition, PSS perceived stress scale, ASC-12 12-item allodynia symptom checklist; d/mo days/month, MIDAS migraine disability assessment, HIT-6 headache impact test
^†Statistical significance assessed with unpaired t-test
^‡Statistical significance assessed with unpaired Wilcoxon rank-sum test

ISSN: 1129-2377