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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: A study of differential microRNA expression profile in migraine: the microMIG exploratory study

Fig. 3

Volcano plot (A) and heatmap (B) of differentially expressed miRNA between healthy controls and patients with migraine. Scattered points from the volcano plot (A) represent miRNAs: the x-axis is the log twofold-change for the ratio healthy controls vs patients with migraine, whereas the y-axis is the log 10 P-value. Colored dots (blue and green) are differentially miRNA statistically significantly over- (right) and under-expressed (left) in patients compared to controls. Blue dots are differentially expressed miRNA with a log twofold-change > 0.50. A heatmap (B) of the 3-miRNA signature selected from the classification algorithm (RF). Columns represent individual arrays, while rows represent specific DE miRNA. The Z-score depicts a measure of distance, in standard deviations, away from the mean. The relative value for each miRNA is depicted by color intensity, with yellow indicating over-expression and red indicating under-expression. HC: healthy controls; MIG: patients with migraine

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