Pre-pregnancy migraine diagnosis, medication use, and spontaneous abortion: a prospective cohort study

Table 5 Association between use of pain medication for migraine and spontaneous abortion (n = 7890)^a

	SABs	Pregnancies	Crude HR	Adjusted HR^b	Adjusted HR^c
Pain medication overall
No pain medication	492	2483	Ref	Ref	Ref
Pain medication for other indications	279	1301	1.11 (0.95–1.28)	0.99 (0.84–1.16)	0.99 (0.84–1.17)
Pain medication for migraine	87	351	1.32 (1.05–1.66)	1.16 (0.91–1.48)	1.15 (0.84–1.47)
Specific pain medication
No pain medication	492	2483	Ref	Ref	Ref
NSAID (non-aspirin)
Use for other indications	189	869	1.08 (0.90–1.28)	0.93 (0.77–1.13)	0.93 (0.76–1.12)
Use for migraine	43	200	1.12 (0.82–1.52)	0.94(0.68–1.31)	0.95 (0.68–1.32)
Acetaminophen
Use for other indications	143	636	1.16 (0.96–1.40)	1.05 (0.86–1.28)	1.06 (0.86–1.30)
Use for migraine	58	234	1.30 (0.99–1.71)	1.15 (0.86–1.54)	1.12 (0.83–1.51)
Aspirin
Use for other indications	13	76	0.86 (0.50–1.49)	0.78 (0.43–1.39)	0.76 (0.42–1.38)
Use for migraine	37	145	1.34 (0.96–1.87)	1.20 (0.81–1.77)	1.21 (0.82–1.79)

^aAssessment based on the most recent follow-up questionnaire before conception.^bAdjusted for baseline age, partner age, education, BMI, smoking, alcohol use, polycystic ovarian syndrome, endometriosis, anxiety, depression, MDI score, physical activity, stress, caffeine intake.^cFurther adjusted for number of pain medication pills and use of any other medication on the follow-up questionnaire closest to conception

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