Pre-pregnancy migraine diagnosis, medication use, and spontaneous abortion: a prospective cohort study

Table 4 Association between preconception migraine medication use and spontaneous abortion, by timing of medication use assessment (n = 7012).

	SABs	Pregnancies	Crude HR	Adjusted HR^a
Migraine medication use, assessed after conception^b
No (non-migraineur)	125	627	Ref	Ref
Yes	15	72	1.10 (0.64–1.87)	1.06 (0.61–1.82)
Migraine medication use, assessed 0–4 weeks before conception
No (non-migraineur)	631	3102	Ref	Ref
Yes	72	311	1.15 (0.90–1.47)	1.13 (0.88–1.43)
Migraine medication use, assessed 5–8 weeks before conception
No (non-migraineur)	344	1572	Ref	Ref
Yes	38	156	1.11 (0.80–1.56)	1.14 (0.81–1.61)
Migraine medication use, assessed > 8 weeks before conception
No (non-migraineur)	906	1049	Ref	Ref
Yes	20	123	1.53 (0.95–2.47)	1.43 (0.87–2.37)

^aAdjusted for baseline age, partner age, education, BMI, smoking, alcohol use, polycystic ovarian syndrome, endometriosis, anxiety, depression, MDI score, physical activity, stress, caffeine intake.^bParticipant was pregnant, but unaware

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