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Table 2 Regions of Interest. The 63 a priori-selected ROIs and their MNI coordinates are shown. For thirty-one of the ROIs, a right-hemisphere and a left-hemisphere ROI was included. Only a midline ROI for periaqueductal gray was included. Each ROI was an 8 mm diameter sphere

From: Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab

Region Name

MNI Coordinates (X, Y, Z)

Anterior Insula

+/−  38

19

−3

Anterior Cingulate

+/− 6

28

24

Middle Cingulate

+/− 10

−7

46

Posterior Cingulate

+/− 8

− 48

39

Posterior Insula

+/− 40

− 14

1

Thalamus

+/− 8

− 21

7

Primary Somatosensory

+/− 46

−24

47

Dorsolateral Prefrontal

+/− 40

39

24

Inferior Lateral Parietal

+/−  57

−48

30

Ventromedial Prefrontal

+/− 6

36

−14

Secondary Somatosensory

+/−  52

−28

21

Somatomotor

+/−  6

1

68

Temporal Pole

+/−  41

10

−32

Amygdala

+/−  22

−1

−22

Middle Temporal

+/−  60

−26

−5

Caudate

+/− 14

13

11

Middle Occipital

+/−  34

− 72

6

Cuneus

+/− 13

− 93

9

Hypothalamus

+/− 6

−6

−12

Lingual Gyrus

+/−  19

− 64

−11

Spinal Trigeminal Nucleus

+/− 6

− 39

− 45

Precuneus

+/−  6

− 58

46

Parieto-Occipital

+/−  51

−64

18

Supramarginal Gyrus

+/− 44

− 42

24

Precentral

+/− 44

−4

40

Middle Frontal

+/−  35

6

52

Pulvinar

+/− 20

−34

3

Fusiform Gyrus

+/− 51

− 59

−9

Superior Parietal

+/− 40

−52

− 49

Dorsal Pons

+/− 6

−36

−27

Cerebellum

+/− 46

− 53

−39

Periaqueductal Gray

−1

−26

−11