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Table 4 Co-occurrence of non-headache symptoms during paired migraine phases

From: Tracking the evolution of non-headache symptoms through the migraine attack

Subject-reported symptoms

Migraine phases

Percentage agreement (%)

k value

p value*

C.I. 95%

Irritability

Prodrome - Headache

52

0.128

0.020

0.024–0.0231

Prodrome - Postdrome

60

0.162

0.005

0.037–0.280

Headache - Postdrome

46

0.113

0.005

0.042–0.183

Difficulty in concentration

Prodrome - Headache

45

0.072

0.047

0.005–0.138

Prodrome - Postdrome

64

0.198

0.004

0.060–0.320

Headache - Postdrome

37

0.055

0.068

0.004–0.105

Fatigue

Prodrome - Headache

49

0.112

0.021

0.021–0.202

Prodrome - Postdrome

57

0.075

0.256

0.056–0.206

Headache - Postdrome

52

0.125

0.017

0.025–0.224

Lethargy

Prodrome - Headache

71

0.397

<  0.001

0.280–0.500

Headache - Postdrome

60

0.173

0.007

0.048–0.298

Prodrome - Postdrome

68

0.195

0.003

0.060–0.330

Yawning

Prodrome – Headache

73

0.297

<  0.001

0.142–0.416

Headache - Postdrome

72

0.192

0.001

0.061–0.323

Prodrome - Postdrome

78

0.237

<  0.001

0.084–0.389

Neck stiffness

Prodrome - Headache

75

0.505

<  0.001

0.400–0.610

Headache - Postdrome

64

0.317

<  0.001

0.416–0.218

Prodrome - Postdrome

74

0.424

<  0.001

0.305–0.543

Food aversion

Prodrome - Headache

63

0.206

<  0.001

0.108–0.304

Headache - Postdrome

61

0.148

<  0.001

0.064–0.232

Prodrome - Postdrome

83

0.058

<  0.001

0.110–0.226

Food craving

Prodrome - Headache

91

0.398

<  0.001

0.187–0.609

Headache - Postdrome

88

0.207

0.001

0.009–0.405

Prodrome - Postdrome

85

0.152

0.023

0.026–0.330

Frequent urination

Prodrome - Headache

88

0.291

<  0.001

0.103–0.479

Headache - Postdrome

81

0.060

0.358

0.087–0.207

Prodrome - Postdrome

88

0.070

0.267

0.096–0.236

Mood disturbance

Prodrome - Headache

61

0.293

<  0.001

0.199–0.387

Headache - Postdrome

52

0.139

0.008

0.042–0.235

Prodrome – Postdrome

75

0.365

<  0.001

0.228–0.502

Phonophobia

Prodrome - Headache

48

0.157

<  0.001

0.088–0.225

Headache - Postdrome

41

0.093

0.011

0.032–0.153

Prodrome - Postdrome

64

0.393

<  0.001

0.258–0.528

Photophobia

Prodrome - Headache

47

0.139

0.001

0.068–0.209

Headache - Postdrome

39

0.073

0.032

0.016–0.129

Prodrome - Postdrome

72

0.271

<  0.001

0.134–0.408

Thirst

Prodrome - Headache

88

0.408

<  0.001

0.228–0.588

Headache - Postdrome

86

0.352

<  0.001

0.172–0.532

Prodrome - Postdrome

87

0.186

0.005

0.006–0.378

Speech difficulty

Prodrome - Headache

69

0.255

<  0.001

0.156–0.354

Headache - Postdrome

68

0.237

<  0.001

0.135–0.339

Prodrome - Postdrome

87

0.244

<  0.001

0.053–0.434

Nausea

Prodrome - Headache

47

0.171

<  0.001

0.140–0.230

Headache - Postdrome

36

0.080

0.005

0.069–0.229

Prodrome - Postdrome

75

0.225

<  0.001

0.366–0.084

Abdominal pain

Prodrome - Headache

95

0.525

<  0.001

0.271–0.779

Headache - Postdrome

95

0.498

<  0.001

0.752–0.244

Prodrome - Postdrome

98

0.793

<  0.001

0.566–1.020

  1. Abbreviations: CI Confidence interval
  2. *Cohen’s kappa coefficients with 95% CIs. Kappa value > 0.3 (fair-good agreement) with a p < 0.05 was considered significant