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Table 2 The Association of previously reported cluster headache loci in the current sample

From: Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan

Chr

Gene

Index SNP

Risk allele

Cona

OR [95%CI]

P1b

P2c

Ref No

1

near RP11-815M8.1

rs11579212

C

2

0.97 [0.78–1.2]

0.30

0.09

6

1

LINC01705/DUSP10

rs6687758

G

1

1.07 [0.94–1.23]

0.23

1.58 × 10–3

7

1

LINC01705/DUSP10

rs12121134

T

2

0.61 [0.22–1.69]

0.21

5.23 × 10–3

7

1

LINC01705

rs545037820

G

3

0.75 [0.50–1.12]

0.02

  

1

near LINC01705

rs2034485

T

3

1.31 [1.16–1.49]

1.16 × 10–6

  

1

DUSP10

rs145531779

C

3

1.43 [1.11–1.83]

0.02

  

2

MERTK

rs4519530

C

2

1.50 [1.32–1.72]

4.69 × 10–12

9.30 × 10–27

7

2

near MERTK

rs6541998

C

2

1.43 [1.25–1.63]

1.86 × 10–8

6.23 × 10–15

6

2

MERTK

rs10188640 rs10188642

A

3

1.52 [1.33–1.73]

8.58 × 10–13

  

2

near LINC01877/SATB2

rs4675692 rs113658130

G C

NA

7

2

LINC01877

rs13394614

G

3

1.34 [1.18–1.52]

5.42 × 10–7

  

2

STAB2

rs13028839

A

3

0.63 [0.52–0.78]

2.81 × 10–8

  

3

MME

rs147564881

C

NA

5

3

MME

rs56208271

A

3

1.61 [1.17–2.22]

4.56 × 10–3

  

3

near MME

rs143162143

C

3

2.29 [1.56–3.36]

1.15 × 10–4

  

4

CLOCK

rs12649507

G

2

0.88 [0.78–1.01]

0.07

1.02 × 10–3

21

4

CLOCK

rs369023808

G

3

1.19 [0.76–1.88]

0.04

  

4

near CLOCK

rs34945396

C

3

0.78 [0.66–0.92]

5.09 × 10–3

  

4

ADH4

rs1126671

T

1

1.72 [0.60–4.93]

0.04

1.46 × 10–3

20

4

ADH4

rs56314548

C

3

0.77 [0.51–1.17]

0.58

  

6

HCRTR2

rs3800539

A

2

1.13 [0.99–1.29]

0.14

0.13

26

6

HCRTR2

rs10498801

A

2

0.88 [0.75–1.02]

0.03

0.34

26

6

HCRTR2

rs2653349

A

2

0.77 [0.57–1.03]

0.49

0.10

23, 24

6

HCRTR2

rs3122156

G

NA

25

6

HCRTR2

rs78769350

G

3

0.69 [0.46–1.06]

0.03

  

6

near UFL1/FHL5

rs2499799

T

2

1.08 [0.85–1.36]

0.74

4.00 × 10–3

6

6

FHL5

rs11153082

G

2

1.19 [1.04–1.35]

1.99 × 10–4

7.54 × 10–11

7

6

FHL5

rs9386670

A

2

1.17 [1.02–1.34]

9.72 × 10–4

1.09 × 10–9

7

6

UFL1

rs2255552

G

3

1.18 [1.04–1.35]

1.83 × 10–4

  

6

FHL5

rs57425973

A

3

1.2 [1.05–1.37]

6.21 × 10–5

  

7

ADCYAP1R1

rs12668955

A

1

1.07 [0.96–1.19]

0.22

1.7 × 10–4

5

7

ADCYAP1R1

rs201504906 rs200124908

C

3

1.72 [1.31–2.26]

1.01 × 10–5

  

12

CRY1

rs8192440

A

1

0.96 [0.66–1.41]

0.42

0.09438

22

  1. Abbreviations: Chr Chromosome, SNP Single nucleotide polymorphism, Con Condition, OR Odds ratio, CI Confidence interval, Risk allele, allele with higher frequency in cases compared to controls, NA Not available
  2. aCondition: 1. Information obtained from real genotyping data. 2. Information derived from imputation data. 3. Most significant SNP within or near the same gene in the imputation data
  3. bThe p values of Cochran-Armitage Trend Test
  4. cThe p values of meta-analysis of the previous studies and the current study