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Table 5 Treatment. Comparison of treatment responses between cluster headache and migraine

From: Debate: Are cluster headache and migraine distinct headache disorders?

 

Migraine

Episodic cluster headache

Triptan

+++

+++

CGRP-mAb

+++

++/−

Oxygen

++

+++

Steroid

++

++

Topiramate

+++

+

Melatonin

+++

++

nVNS

++

++

SPG modulation

++/− (chronic migraine)a

++ (chronic cluster headache)b

  1. +++ efficacy proved in ≥2 randomized placebo-controlled studies
  2. ++ efficacy proved in 1 randomized placebo-controlled study
  3. + open label studies
  4. - negative randomized placebo-controlled study
  5. nVNS Non-invasive vagus nerve stimulation, SPG Sphenopalatine ganglion
  6. aSPG block
  7. bSPG stimulation