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Fig. 6 | The Journal of Headache and Pain

Fig. 6

From: A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine

Fig. 6

c-Fos activation map of cortical structures in the LEV-induced chronic migraine model. A. Representative pictures of c-Fos (red) and NeuN (green) immunofluorescence labeling in the mPFC. Scale bars =100 μm. B-C. mPFC showed a significant increase of c-Fos+ cell density (B) and the percentage of c-Fos+ cells in NeuN+ cells (C). alleviated by olcegepant. n = 5/group. D. Representative pictures of c-Fos (red) and NeuN (green) immunofluorescence labeling in the ACC. Scale bars =100 μm. E–F. In the ACC, no significant differences in c-Fos+ cell density (E) and the percentage of c-Fos+ cells in NeuN cells (F) were found. n = 5/group. One-way ANOVA with the Tukey post hoc tests, * P < 0.05, **P < 0.01. Abbreviations: mPFC, medial prefrontal cortex; ACC, anterior cingulate cortex; OLC, olcegepant; LEV, levcromakalim

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