Fig. 5
From: A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine
CGRP receptor antagonist (olcegepant) alleviated acute hyperalgesia in the LEV-induced chronic migraine model. A. Representative schematic diagrams and procedures for the behavioral tests (Created with BioRender.com). B-C. Repeated LEV administration induced mechanical hyperalgesia of periorbital area (B) and hindpaw (C), alleviated by OLC. Two-way ANOVA with the Tukey post hoc tests, *P < 0.05, **P < 0.01, LEV group compared with the VEH group, n = 8/group; #P < 0.05, # # P < 0.01, LEV group compared with the LEV+OLC group, n = 8/group. Abbreviations: VEH, vehicle; OLC, olcegepant; LEV, levcromakalim