Fig. 1
From: Alterations in metabolic flux in migraine and the translational relevance
Hypothesised alterations in metabolic flux which may contribute to migraine pathophysiology. The activity of numerous vital metabolic pathways is altered in migraine patients, which may lead to the upregulation of nociceptive peptides. Moreover, metabolic hormones including insulin and amylin act on receptors implicated in nociception in trigeminal nerves and vasodilation in endothelial cells, pathways which are both involved in migraine pathophysiology. α-KG; α-ketoglutarate, ADP; Adenosine di-phosphate, AMY1; Amylin type 1 receptor, ATP; Adenosine tri-phosphate, CGRP; Calcitonin gene related peptide, CoQ; CoenzymeQ10, Cyt c; Cytochrome C, FAD; Flavin adenine dinucleotide, GLUT; Glucose transporter, TCA; tricarboxylic acid cycle