Interictal vs Healthy | ||||
---|---|---|---|---|
Target | logFC | Node Strength | Description | Pain/inflammation related disease/processes (if applicable) |
PLCXD2 | -1.337 | 1 | phosphatidylinositol specific phospholipase C X domain containing 2 | |
TNF | 2.814 | -1 | tumor necrosis factor | migraine, high pain and high fatigue, cancer pain [53], painful neuropathy [54], rheumatoid arthritis [55], Crohn disease [55] |
EGR1 | 2.616 | -1 | early growth response 1 | regulates proteins involved in inflammation [56] |
EREG | 3.063 | -1 | epiregulin | temporomandibular disorder [53] |
CD83 | 2.504 | -1 | CD83 molecule | upregulated by oxidative stress; maturation marker, antiinflammatory effects [57, 58] |
NFKBIA | 1.861 | -1 | NFKB inhibitor alpha | cancer pain [53] |
IER3 | 1.810 | -1 | immediate early response 3 | sarcoidosis [55] |
TNFAIP6 | 2.464 | -1 | tumor necrosis factor alpha-induced protein 6 | rheumatoid arthritis [59] |
ID1 | 1.723 | -1 | inhibitor of DNA binding 1, HLH protein | response to oxidative stress [60] |
OSR2 | 1.936 | -1 | odd-skipped related transciption factor 2 | upregulated in mirror image pain in rat CRPS model [61] |
NR4A2 | 1.752 | -1 | nuclear receptor subfamily 4 group A member 2 | associated with dopaminergic neuron differentiation and dopamine biosynthetic processes [62], neuroinflammation [63] mediates production of inflammatory cytokines[64] |
CNTNAP3 | 2.178 | -1 | contactin associated protein-like 3 | Crohn’s Disease [65], |
FOSB | 1.524 | -1 | FosB proto-oncogene, AP-1 transcription factor subunit | |
IL6 | 1.826 | -1 | interleukin 6 | neuraxial pain, analgesia, musculoskeletal pain, cancer pain, arthritis; irritable bowel syndrome; sciatica intervertebral disc disease pain [53] |
EGR3 | 1.694 | -1 | early growth response 3 | neuropathy[56] |
DUSP1 | 1.265 | -1 | dual specificity phosphatase 1 | antiinflammatory in neuropathic pain [68], alleviates neuroinflammation and neuronal injury [69] |
SOCS3 | 1.284 | -1 | suppressor of cytokine signalling 3 | regulates cytokine signal transduction[56], chronic pain [66] |
SAT1 | 1.147 | -1 | spermidine/spermine N1-acetyltransferase 1 | neuroinflammation [70] |
RGS1 | 1.681 | -1 | regulator of G protein signalling 1 | undifferentiated spondylarthritis [71] |
PLAU | 1.312 | -1 | plasminogen activator, urokinase | psoriasis, ulcerative colitis, Crohn's disease, inflammatory bowel disease [55] |
MIPOL1 | 1.252 | -1 | mirror-image polydactyly 1 | nasopharyngeal carcinoma [72] |
JUNB | 1.059 | -1 | JunB proto-oncogene, AP-1 transcription factor subunit | psoriasis [73] |
SGK1 | 0.975 | -1 | serum/glucocorticoid regulated kinase 1 | pain developement [74] |
MAP3K7CL | 0.878 | -1 | MAP3K7 C-terminal like | non‐small cell lung cancer [75] |
CXCL8 (IL8) | 2.806 | -2 | C-X-C motif chemokine ligand 8 (interleukin 8) | cancer pain [53] |
PLAUR | 1.428 | -2 | plasminogen activator, urokinase receptor | inflammatory bowel disease [76] |
DUSP2 | 1.521 | -2 | dual specificity phosphatase 2 | endometriosis, cancer, immune and inflammatory resonses [77] |
RBKS | 1.202 | -2 | ribokinase | |
GXYLT2 | 1.888 | -3 | glucoside xylosyltransferase 2 | ulcerative colitis [78] |
SOD2 | 1.429 | -4 | superoxide dismutase 2 | migraine [55] |
SOCS1 | 1.033 | -4 | suppressor of cytokine signalling 1 | Crohn's disease, psoriasis [55] |