Skip to main content

Table 8 Common targets, with similar changes in mRNA- and small RNA sequencing data for validation of predictions at mRNA level in interictal vs healthy comparison. Description and pain phenotype matches based on Human Pain Gene [53], Pain Research Forum [54], DisGeNET [55], and GeneCards [56], complemented with other literature data. logFC: logarithm of the fold change of measured mRNA data

From: Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress

Interictal vs Healthy

Target

logFC

Node Strength

Description

Pain/inflammation related disease/processes

(if applicable)

PLCXD2

-1.337

1

phosphatidylinositol specific phospholipase C X domain containing 2

 

TNF

2.814

-1

tumor necrosis factor

migraine, high pain and high fatigue, cancer pain [53], painful neuropathy [54], rheumatoid arthritis [55], Crohn disease [55]

EGR1

2.616

-1

early growth response 1

regulates proteins involved in inflammation [56]

EREG

3.063

-1

epiregulin

temporomandibular disorder [53]

CD83

2.504

-1

CD83 molecule

upregulated by oxidative stress; maturation marker, antiinflammatory effects [57, 58]

NFKBIA

1.861

-1

NFKB inhibitor alpha

cancer pain [53]

IER3

1.810

-1

immediate early response 3

sarcoidosis [55]

TNFAIP6

2.464

-1

tumor necrosis factor alpha-induced protein 6

rheumatoid arthritis [59]

ID1

1.723

-1

inhibitor of DNA binding 1, HLH protein

response to oxidative stress [60]

OSR2

1.936

-1

odd-skipped related transciption factor 2

upregulated in mirror image pain in rat CRPS model [61]

NR4A2

1.752

-1

nuclear receptor subfamily 4 group A member 2

associated with dopaminergic neuron differentiation and dopamine biosynthetic processes [62], neuroinflammation [63] mediates production of inflammatory cytokines[64]

CNTNAP3

2.178

-1

contactin associated protein-like 3

Crohn’s Disease [65],

FOSB

1.524

-1

FosB proto-oncogene, AP-1 transcription factor subunit

chronic pain [66], inflammatory pain [67]

IL6

1.826

-1

interleukin 6

neuraxial pain, analgesia, musculoskeletal pain, cancer pain, arthritis; irritable bowel syndrome; sciatica intervertebral disc disease pain [53]

EGR3

1.694

-1

early growth response 3

neuropathy[56]

DUSP1

1.265

-1

dual specificity phosphatase 1

antiinflammatory in neuropathic pain [68], alleviates neuroinflammation and neuronal injury [69]

SOCS3

1.284

-1

suppressor of cytokine signalling 3

regulates cytokine signal transduction[56], chronic pain [66]

SAT1

1.147

-1

spermidine/spermine N1-acetyltransferase 1

neuroinflammation [70]

RGS1

1.681

-1

regulator of G protein signalling 1

undifferentiated spondylarthritis [71]

PLAU

1.312

-1

plasminogen activator, urokinase

psoriasis, ulcerative colitis, Crohn's disease, inflammatory bowel disease [55]

MIPOL1

1.252

-1

mirror-image polydactyly 1

nasopharyngeal carcinoma [72]

JUNB

1.059

-1

JunB proto-oncogene, AP-1 transcription factor subunit

psoriasis [73]

SGK1

0.975

-1

serum/glucocorticoid regulated kinase 1

pain developement [74]

MAP3K7CL

0.878

-1

MAP3K7 C-terminal like

non‐small cell lung cancer [75]

CXCL8 (IL8)

2.806

-2

C-X-C motif chemokine ligand 8 (interleukin 8)

cancer pain [53]

PLAUR

1.428

-2

plasminogen activator, urokinase receptor

inflammatory bowel disease [76]

DUSP2

1.521

-2

dual specificity phosphatase 2

endometriosis, cancer, immune and inflammatory resonses [77]

RBKS

1.202

-2

ribokinase

 

GXYLT2

1.888

-3

glucoside xylosyltransferase 2

ulcerative colitis [78]

SOD2

1.429

-4

superoxide dismutase 2

migraine [55]

SOCS1

1.033

-4

suppressor of cytokine signalling 1

Crohn's disease, psoriasis [55]