Table 7 Gene Ontology (GO) enrichment analysis (biological processes) of all miRNA targets in interictal vs healthy and ictal vs interictal comparisons. The top ten predicted up-and downregulated processes with the highest fold enrichment values are presented here, where sorting is based on the fold enrichment of the most specific subclasses

Targets predicted to be downregulated

 flavonoid glucuronidation (GO:0052696)

10.28

7.09E-04

postsynaptic specialization organization (GO:0099084)

3.47

3.09E-02

 negative regulation of cellular glucuronidation (GO:2001030)

10.28

2.04E-03

regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)

3.47

3.09E-02

 negative regulation of glucuronosyltransferase activity (GO:1904224)

10.28

2.03E-03

postsynaptic density organization (GO:0097106)

3.47

3.08E-02

 regulation of glucuronosyltransferase activity (GO:1904223)

10.28

2.02E-03

negative regulation of smooth muscle cell migration (GO:0014912)

3.30

1.49E-02

 regulation of cellular glucuronidation (GO:2001029)

9.14

3.21E-03

hippo signalling (GO:0035329)

2.85

3.17E-02

 xenobiotic glucuronidation (GO:0052697)

8.41

1.88E-03

regulation of mesenchymal cell proliferation (GO:0010464)

2.72

1.91E-02

 flavonoid metabolic process (GO:0,009,812)

6.43

3.10E-03

roof of mouth development (GO:0060021)

2.47

7.20E-05

 cellular glucuronidation (GO:0052695)

6.28

1.67E-03

regulation of smooth muscle cell migration (GO:0014910)

2.41

4.74E-03

 uronic acid metabolic process (GO:0006063)

5.36

2.17E-03

regulation of dendritic spine morphogenesis (GO:0061001)

2.41

1.85E-02

 glucuronate metabolic process (GO:0019585)

5.36

2.16E-03

positive regulation of epithelial to mesenchymal transition (GO:0010718)

2.36

2.89E-02

Targets predicted to be upregulated

 negative regulation of platelet activation (GO:0010544)

3.35

3.79E-02

regulation of cell projection organization (GO:0031344)

2.03

3.79E-02

 G1 phase (GO:0051318)

3.28

3.00E-02

neuron development (GO:0048666)

1.95

2.14E-02

 mitotic G1 phase (GO:0000080)

3.28

3.00E-02

intracellular protein transport (GO:0006886)

1.79

3.90E-02

 regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)

3.27

1.87E-03

neuron differentiation (GO:0030182)

1.78

3.58E-02

 response to muscle stretch (GO:0035994)

3.22

2.35E-02

generation of neurons (GO:0048699)

1.78

1.80E-02

 negative regulation of cyclin-dependent protein kinase activity (GO:1904030)

3.18

6.66E-03

neurogenesis (GO:0022008)

1.72

1.79E-02

 regulation of sister chromatid cohesion (GO:0007063)

3.13

3.85E-02

intracellular transport (GO:0046907)

1.62

3.97E-02

 negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)

3.11

1.12E-02

cellular macromolecule localization (GO:0070727)

1.61

3.15E-02

 regulation of histone H3-K9 methylation (GO:0051570)

3.09

3.02E-02

cellular protein localization (GO:0034613)

1.60

3.66E-02

 positive regulation of pri-miRNA transcription by RNA polymerase II (GO:1902895)

3.05

2.47E-03

nitrogen compound transport (GO:0071705)

1.56

3.40E-02