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Table 5 Top 15 pathways containing the list of GO results from the Mirpath v3 webtool analysis

From: Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress

TermID

Name

Frequency

p-value

Number of genes

Number of miRNAs

Interictal vs healthy

 GO:0048011

neurotrophin TRK receptor signalling pathway

0.07

1.22E-51

161

24

 GO:0038095

Fc-epsilon receptor signalling pathway

0.14

6.77E-39

104

24

 GO:0035666

TRIF-dependent toll-like receptor signalling pathway

0.04

6.03E-15

43

20

 GO:0034166

toll-like receptor 10 signalling pathway

0.01

4.80E-14

38

19

 GO:0,038,123

toll-like receptor TLR1:TLR2 signalling pathway

0.01

1.63E-13

39

20

 GO:0034146

toll-like receptor 5 signalling pathway

0.01

1.82E-11

38

19

 GO:0018279

protein N-linked glycosylation via asparagine

0.13

3.52E-07

47

19

 GO:0006921

cellular component disassembly involved in execution phase of apoptosis

0.12

2.29E-06

23

19

 GO:0002576

platelet degranulation

0.05

2.34E-05

32

18

 GO:0050690

regulation of defense response to virus by virus

0.01

8.27E-04

16

13

 GO:0061418

regulation of transcription from RNA polymerase II promoter in response to hypoxia

0.07

8.27E-04

16

16

 GO:0035872

nucleotide-binding domain. leucine rich repeat containing receptor signalling pathway

0.08

1.04E-03

18

16

 GO:0034199

activation of protein kinase A activity

0.02

4.86E-04

10

8

 GO:0071377

cellular response to glucagon stimulus

0.06

5.90E-03

18

16

 GO:0036109

alpha-linolenic acid metabolic process

0.06

6.51E-03

7

6

Ictal vs interictal

 GO:0048011

neurotrophin TRK receptor signalling pathway

0.07

2.39E-44

157

21

 GO:0038095

Fc-epsilon receptor signalling pathway

0.14

2.95E-34

102

19

 GO:0006921

cellular component disassembly involved in execution phase of apoptosis

0.12

3.28E-10

29

16

 GO:0018279

protein N-linked glycosylation via asparagine

0.13

1.91E-09

54

16

 GO:0038123

toll-like receptor TLR1:TLR2 signalling pathway

0.01

2.20E-09

35

15

 GO:0038124

toll-like receptor TLR6:TLR2 signalling pathway

0.04

2.20E-09

35

15

 GO:0034166

toll-like receptor 10 signalling pathway

0.01

4.66E-09

33

15

 GO:0034146

toll-like receptor 5 signalling pathway

0.01

3.68E-07

33

15

 GO:0006369

termination of RNA polymerase II transcription

0.07

1.35E-04

23

14

 GO:0002576

platelet degranulation

0.05

3.17E-04

31

15

 GO:0022400

regulation of rhodopsin mediated signalling pathway

0.06

4.62E-04

16

9

 GO:1900740

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signalling pathway

0.02

2.12E-03

18

15

 GO:0007603

phototransduction. visible light

0.07

4.18E-03

38

14

 GO:0050690

regulation of defense response to virus by virus

0.01

6.52E-03

13

8

 GO:0034199

activation of protein kinase A activity

0.02

7.95E-03

10

8