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Table 1 Description of the study subjects, main demographic, and clinical characteristics. Mean values (with 95% confidence intervals) of the selected parameters in migraineurs (interictal and ictal phase) and healthy control groups. Headache pain was evaluated with the VAS (visual analogue scale). Categories are as follows: 1–4 grade (1), 5–7 grade (2), 8–10 grade (3)

From: Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress

 

Interictal

(n = 16)

Ictal

(n = 8)

Healhy control

(n = 12)

P—value

Age

34.62 (28.66—40.58)

36.87 (26.93—46.81)

30.75 (27.95—33.55)

0.91

Body mass index (BMI)

21.95 (19.84—24.06)

21.90 (19.59—24.20)

23.28 (21.39—25.17)

0.36

Last meal (hours ago)

6.67 (3.65—9.68)

6.62 (1.64—11.61)

3.83 (0.66—6.99)

0.21

 

Co-morbidities and therapy

 

Known other diseases (%)

50 (24—75)

50 (12—87)

 

1.00

Regular medication (except attack therapy) (%)

31 (7—54)

38 (1—73)

 

0.76

Hormonal contraceptives (%)

37 (12—62)

25 (0—57)

25 (0—51)

0.73

Antimigraine prophylactic therapy (%)

0

0

  
 

Clinical features of the headache

 

Disease duration (years)

13.18 (8.95—17.41)

15.5 (7.98—23.01)

 

0.51

Attack frequency (attack/year)

23.93 (16.65—31.22)

21.87 (10.95—32.79)

 

0.62

Visual analogue scale category (VAS)

2.68 (2.45—2.92)

2.62 (2.26—2.98)

 

0.76

Allodynia (%)

31 (7—54)

50 (12—87)

 

0.38

Chronic pain (%)

18 (0—38)

12 (0—37)

 

0.70

Menstruation-headache relationship (sensitive) (%)

37 (12—62)

37 (1—73)

 

1.00

Migraineurs in the family (%)

68 (0.45—0.92)

62 (26—98)

 

0.76

Regular exercise (%)

56 (30—81)

62 (26—98)

17 (0—39)

0.06

 

Features of attacks before samplings

 

Number of attacks in the previous month

2.62 (1.4—3.84)

0.87 (0.18—1.56)

 

0.03

Last attack (days ago)

20.25 (3.26—37.23)

36.62 (3.38—69.86)

 

0.04

Beginning of attack before ictal sampling (hours)

 

6.31 (1.24—11.38)

  

Actual VAS

 

5.62 (4.79—6.45)