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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress

Fig. 3

Visualisation of miRNA-mRNA interaction network (EntOptLayout) and target prediction analysis by miRNAtarget.com™ (interictal vs healthy). Rectangle and oval-shaped nodes represent miRNAs and mRNA targets of miRNAs, respectively. The node size and colour intensity of mRNA targets change according to node strength values. Down (blue)- and upregulated (red) interacting miRNAs suggest a central role of upregulated (orange) cyclin T2 (CCNT2) and kelch like family member 15 (KLHL15) and downregulated (light-blue) cell adhesion molecule 2 (CADM2) mRNAs. Whole predicted miRNA-target interaction network is shown on panel A. To highlight important mRNA targets, targets with an absolute node strength value less than or equal to 1 (i.e. -1, 0 or 1) presented uniformly smaller and fainter. On panel B, a subnetwork of the whole predicted miRNA-target interaction network is shown, containing only those target mRNAs (marked with a red oval on panel A) and their interacting miRNAs that were validated by RNA sequencing. The same arrangement as in the whole network with a proportional magnification of the target mRNAs was applied

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The Journal of Headache and Pain

ISSN: 1129-2377

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