Fig. 8
From: HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain
Systemic anti-HMGB1 mAb simultaneously alleviated pain sensitization and anxiety after p-IONX. a Schedule of experimental procedures. b Paw withdrawal thresholds to mechanical stimulation and noxious heat stimulation at the left hind paw and head withdrawal threshold to noxious heat stimulation at the left vibrissal pad before and after p-IONX. ## and ### indicate P < 0.01 and 0.001, respectively, compared with the saline-treated group at the same time points, two-way ANOVA with Bonferroni post hoc. c Anxiety-like behaviors measured by EPM, LDB and OFT on D15/16 after p-IONX. * and *** indicate P < 0.05 and 0.001, respectively, compared with the saline-treated group, ordinary one-way ANOVA with Dunnett post hoc. n = 8/group