Table 1 CSD onset latency and frequency with different concentrations of topical ouabain application in the mouse brain (total volume for each animal equals to 5 μl in all experiments). (none: no CSD detected, rare: 1–2 CSDs/h, frequent: ≥ 3 CSDs/h)
Concentration (mM) | Latency to CSD onset (min) (mean ± SE) | Latency to CSD onset (min) (range) | CSD pattern (frequency) |
|---|---|---|---|
0.1 | 46.3 ± 4.4 | 6—68 | % 25 none % 50 rare % 25 frequent |
0.15 | 40.2 ± 4.2 | 14—68 | % 20 none % 28 rare % 52 frequent |
0.3 | 20.7 ± 5.6 | 6—33 | %100 frequent |
1 | 13.2 ± 2.5 | 7—14 | %100 frequent |